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Selected publications:


  • Kao C, Chandna R, Ghode A, Dsouza C, Chen M, Larsson A, Lim SH, Wang M, Cao Z, Zhu Y, Anand GS. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine. 2018 Jun. [PUBMED]
  • Boon PL, Saw WG, Lim XX, Raghuvamsi PV, Huber RG, Marzinek JK, Holdbrook DA, Anand GS, Grüber G, Bond PJ. Partial Intrinsic Disorder Governs the Dengue Capsid Protein Conformational Ensemble. ACS Chemical Biology. 2018 May 24;13(6):1621-30. [PUBMED]


  • Lim XX, Chandramohan A, Lim XY, Crowe Jr JE, Lok SM, Anand GS. Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface. Structure. 2017 Sep 5;25(9):1391-402. [PUBMED]
  • Tulsian NK, Krishnamurthy S, Anand GS. Channeling of cAMP in PDE-PKA complexes promotes signal adaptation. Biophysical Journal. 2017 Jun 20;112(12):2552-66. [PUBMED]
  • Chandramohan A, Tulsian NK, Anand GS. Dissecting Orthosteric Contacts for a Reverse-Fragment-Based Ligand Design. Analytical Chemistry. 2017 Jul 14;89(15):7876-85. [PUBMED]
  • Ghosh M, Wang LC, Ramesh R, Morgan LK, Kenney LJ, Anand GS. Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays. Biophysical Journal. 2017 Feb 28;112(4):643-54. [PUBMED]
  • Lim XX, Chandramohan A, Lim XY, Bag N, Sharma KK, Wirawan M, Wohland T, Lok SM, Anand GS. Conformational changes in intact dengue virus reveal serotype-specific expansion. Nature Communications. 2017 Feb 10;8:14339. [PUBMED]


  • Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase. Scientific Reports. 2016;6. [PUBMED]
  • Husain N, Tulsian NK, Wang LC, Anand GS, Sivaraman J. Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions. Scientific Reports. 2016;6. [PUBMED]
  • Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand GS. Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: Implications for Fragment-based drug design. PLoS Computational Biology. 2016 Jun 2;12(6):e1004840. [PUBMED]


  • Krishnamurthy S, Tulsian NK, Chandramohan A, Anand GS. Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling. Biophysical Journal. 2015 Sep 15;109(6):1251-63. [PUBMED]


  • Krishnamurthy S, Moorthy BS, Lim XX, Lim XS, Bharatham K, Tulsian NK, Mihalek I, Anand GS. Active site coupling in PDE: PKA complexes promotes resetting of mammalian cAMP signaling. Biophysical Journal. 2014 Sep 16;107(6):1426-40. [PUBMED]
  • Krishnamurthy S, Veesler D, Khayat R, Snijder J, Huang R, Heck AJ, Johnson J, Anand GS. Distinguishing direct binding interactions from allosteric effects in the protease–HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry. Bacteriophage. 2014 Dec 15;4(4):e959816. [PUBMED]
  • Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA viral capsid in complex with its maturation protease. Structure. 2014 Feb 4;22(2):230-7. [PUBMED]


  • Krishnamurthy S, Moorthy BS, Liqin L, Anand GS. Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: capturing transient ternary complexes by HDXMS. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2013 Jun 30;1834(6):1215-21. [PUBMED]


  • Wang LC, Morgan LK, Godakumbura P, Kenney LJ, Anand GS. The inner membrane histidine kinase EnvZ senses osmolality via helix‐coil transitions in the cytoplasm. The EMBO Journal. 2012 May 30;31(11):2648-59. [PUBMED]
  • Nambi S, Badireddy S, Visweswariah SS, Anand GS. Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases. Journal of Biological Chemistry. 2012 May 25;287(22):18115-29. [PUBMED]
  • Moorthy BS, Anand GS. Multistate allostery in response regulators: phosphorylation and mutagenesis activate RegA via alternate modes. Journal of Molecular Biology. 2012 Apr 13;417(5):468-87. [PUBMED]


  • Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Molecular & Cellular Proteomics. 2011 Mar 1;10(3):M110-004390. [PUBMED]
  • Moorthy BS, Gao Y, Anand GS. Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination. Molecular & Cellular Proteomics. 2011 Feb 1;10(2):M110-002295. [PUBMED]


  • Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Cyclic AMP-and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RIα) subunits of cyclic AMP-dependent protein kinase. Molecular & Cellular Proteomics. 2010 Oct 1;9(10):2225-37. [PUBMED]


  • Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, Van-Den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J. Structural basis for the inhibition mechanism of human cystathionine γ-lyase, an enzyme responsible for the production of H2S. Journal of Biological Chemistry. 2009 Jan 30;284(5):3076-85. [PUBMED]

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