Dr Kini's Laboratory








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30 Patent applications

148 Research publications

29 Reviews

181 Conference papers

11 Book chapters

Prof. R.M Kini - One of the most cited authors in toxin research (Toxicon 44(2004) 345-359)

Editor of Monograph/ Special Issues

Selected Recent Publications (2006-2009)

1. Kang, T. S., Jois, S. D. S. and Kini, R. M.: Solution structures of two structural isoforms of CMrVIA λ/χ-conotoxin. Biomacromolecules, 7, 2337-2346, 2006.

2. Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., Servent, D., Ménez, R., Stura, E., Ménez, A. and Kini, R. M.: Denmotoxin, a Three-finger Toxin from the Colubrid Snake Boiga dendrophila (Mangrove Catsnake) with Bird-specific Activity. J. Biol. Chem., 281, 29030-29041, 2006.

3. Reza, M. A., Swarup, S. and Kini, R. M.: Gene structures of two functionally diverse prothrombin activators, Trocarin D and coagulation factor X in Tropidechis carinatus snake: gene duplication and recruitment of factor X gene to the venom gland. J. Thrombos. Haemostas. , 5, 117-126, 2007.

4. Gayathri, S., Lakshminarayanan, R., Weaver, J. C., Morse, D. E., Kini, R. M. and Valiyaveettil, S.: An in vitro study of magnesium-calcite biomineralization in the skeletal materials of seastar, Pisaster giganteus. Chem. Eur. J., 13, 3262-3268, 2007.

5. Nair, D. G., Fry, B. G., Alewood, P., Kumar, P. P. and Kini, R. M.: Antimicrobial activity of omwaprin, a new member of waprin family of snake venom proteins. Biochem. J., 402, 93-104, 2007.

6. Lumsden, N. G., Banerjee, Y., Kini, R. M. , Kuruppu, S. and Hodgson, W. C.: Isolation and characterization of rufoxin, a novel protein exhibiting neurotoxicity from the venom of Psammophiine, Rhamphiophis oxyrhynchus (Rufous beaked snake). Neuropharmacology, 52, 1065-1070, 2007.

7. Kang, T. S., Radic, Z., Talley, T. T., Jois, S. D. S., Taylor, P. and Kini, R. M. : Protein folding determinants: structural features determining alternative disulfide pairing in α - and λ/χ -conotoxin s. Biochemistry, 46, 3338-3355, 2007.

8. Nandhakishore, R., Pung, Y. F., Zhu, Y. Z., Wong, P. T. H., Kumar, P. P. and Kini, R. M.: β- Cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity. FASEB J., 21, 3685-3695, 2007.

9. Pahari, S., Bickford, D., Fry, B. G. and Kini, R. M. : Expression pattern of three-finger toxin and phospholipase A2 genes in the venom glands of two sea snakes, Lapemis curtus and Acalyptophis peronii: comparison of evolution of these toxins in land snakes, sea kraits and sea snakes. BMC Evol. Biol., 7 , 175, 2007.

10. Koh, C. Y., Kazimirova, M., Trimnell, A., Takac, P., Labuda, M., Nuttall, P. and Kini, R. M. : Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick. J. Biol. Chem., 282 , 29101-29113, 2007.

11. Pahari, S., Mackessy, S. P. and Kini, R. M. : The venom gland transcriptome of the desert Massasauga rattlesnake (Sistrurus catenatus edwardsii): towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea). BMC Evol. Biol. , 8, 115, 2007.

12. Lakshminarayanan, R., Vivekanandan, S., Samy, R., Banerjee, Y., Chi-Jin, E., Teo, K. W., Jois, S., Kini, R. M. and Valiyaveettil, S.: Structure, self-assembly and dual role of a beta-defensin like peptide from the Chinese soft-shelled turtle eggshell matrix. J. Am. Chem. Soc. , 130, 4660, 2008.

13. Doley , R., Nguyen, T. N. B., Reza M. A. and Kini, R. M. : Unusual Accelerated Rate of Deletions and Insertions in Toxin Genes in the Venom Glands of the Pygmy Copperhead (Austrelaps labialis) from Kangaroo Island. BMC Evol. Biol. 8: 70, 2008.

14. Doley, R., Pahari, S., Mackessy, S. and Kini, R. M. : Accelerated exchange of exon segments in Viperid three-finger oxin genes (Sisturus catenatus edwardsii; Desert Massasauga). BMC Evol. Biol. 8: 196, 2008.

15. Zhou, X., Sun, Q., Kini, R.M. and Sivaraman, J. : A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry. Protein Sci. 17: 1798, 2008.

16. Pawlak, J., Mackessy, S.P., Sixberry, N.M., Stura, E.A., Le Du, M.H., Ménez, R., Foo, C.S., Ménez, A., Nirthanan, S. and Kini, R.M. : Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon specific neurotoxicity. FASEB J. 23: 534, 2009.

17. Kang, T.S. and Kini, R.M. : Structural determinants of protein folding. Cell Mol Life Sci. 14: 2341, 2009.

18. Doley, R. and Kini, R.M.: Protein complexes in snake venom. Cell Mol Life Sci. 17: 2851, 2009.

19. Doley, R., Mackessy, S.P and Kini,R.M.: Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins. BMC Evol. Biol. 30: 146, 2009.

20. Koh, C.Y., Kazimirova, M., Nuttall, P.A., and Kini, R.M.: Noncompeptitive inhibitior of thrombin. Chembiochem. 10: 2155, 2009.

21. Koh, C.Y., and Kini, R.M.: Molecular diversity of anticoagulants from haematophagus organisms. Thromb haemost. 102: 437, 2009.

22. Kwong, S., Woods, A.E., Mirtschin, P.G., Ge, R., and Kini, R.M.: The recruitment of blood coagulation factor X into snake venom gland as a toxin: the role of promoter Cis-elements in its expression. Thromb. Haemost. 102: 469, 2009.

23. Xiang, W., Ke, Z., Y. Zhang, Y., Cheng, G. H.-Y., Irwan, I. D., Sulochana, K. N., Potturi, P., Wang, Z., Yang, H., Wang, J., Zhuo, L., Kini, R. M. and Ge, R.: Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumor growth in mice. J. Cell. Mol. Med., in Press, 2010.




 Complete List of Publications

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