Job Opportunities in DBS

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    laboratory technologist (10 May 2016)

    research assistant (20 apr 2016)

    positions in cryo-em (8 apr 2016)

    research assistant (22 mar 2016)

    Research assistant and research fellow (21 Mar 2016)

    research assistant (mar 2016)

    Research assistant in statistical optics for electron microscopy (7 mar 2016)

    Research fellow (23 Dec 2015)


    Laboratory Technologist

    Job Purpose:
    To provide support to ongoing research project that aims to dissect the evolution of novel wing patterns in butterflies.

    Duties and responsibilities:

  • To clone candidate cis-regulatory elements into a reporter vector.
  • To inject butterfly embryos with vector and produce transgenic lines of butterflies.
  • To help with animal rearing and screening of transgenic lines.
  • To image transgenic lines with a fluorescent scope.
  • Qualification and requirements:

  • Undergraduate degree in Biology with research experience (UROPS or ideally Honors project) in some aspect of molecular, or developmental biology related to the main duties and responsibilities described above.
  • One or more years of experience are preferred.
  • Interested applicants, please submit your CV to:

    Associate Professor Antonia Monteiro
    Email: dbsfmaa@nus.edu.sg
    Contact: 66012108


    Research Assistant

    We are looking for a Full-time Research Assistant to work in the Freshwater and Invasion Biology Laboratory.

    Responsibilities:
    Under the direction of the project manager, primary tasks will include conducting: 

    1. Field studies in freshwater habitats involving fish, macroinvertebrate and plankton sampling
    2. Laboratory based work involving sorting and processing of specimens and data collected during field work
    3. Technical and report/scientific paper writing

    Requirements include:

    1. BSc (Hons) or equivalent, with prior experience in freshwater ecology preferred
    2. Good organizational skills and excellent attention to detail is essential
    3. Possess leadership qualities, self-motivated, responsible, and a fast learner
    4. Independent, but also able to work in a collaborative, team-oriented environment
    5. Physically fit for extended periods of field work
    6. A valid Singapore Class 3 driving license is highly desirable
    7. Some weekend flexibility may be required
    8. Proficiency in Microsoft Office and Adobe applications
    9. Data analysis (using R, SPSS, Statistica and Primer); training will be provided if necessary

    This is a 1 year (renewable) grant-funded position. Interested individuals are invited to send your applications that include a CV and three recommendation letters, with a cover letter to:

    Assistant Professor Darren Yeo Chong Jinn
    Department of Biological Sciences
    National University of Singapore,
    14, Science Drive 4, Singapore 117543
    Email: dbsyeod@nus.edu.sg

    For more information about our research, please visit http://www.dbs.nus.edu.sg/lab/FW_lab/Main.htm
    We regret that only shortlisted applicants will be contacted for interviews. Closing date for application is 27 May 2016.


    Positions in Cryo-EM - Assistant Professor

    The Department of Biological Sciences (DBS), National University of Singapore (NUS), invites applications for a tenure track faculty position at the Assistant Professor level in electron cryomicroscopy (cryo-EM). Candidates with an excellent publication record in cryo-EM research, including single-particle approaches and tomography, are encouraged to apply. The candidate is expected to develop a highly competitive research program and will have many opportunities to collaborate with colleagues in DBS.

    The position is based at the Centre for BioImaging Sciences (CBIS) in the Department of Biological Sciences. CBIS members have broad imaging expertise including crystallography, light microscopy, single-particle cryo-EM, electron tomography, AFM, and computational imaging (http://cbis.nus.edu.sg/). CBIS hosts a state-of-the-art EM facility containing T12, JEOL 2200FS, JEOL 2010, and Titan Krios cryoTEMs. All four cryo-EMs are equipped with direct-detection cameras that are capable of “movie-mode” data collection. Furthermore, the Titan Krios and JEOL 2200FS are both equipped with second-generation Volta-style phase plates. This advanced imaging facility is supported by dedicated microscopy and IT personnel. Image analysis and data handling are done on high-end computer clusters, which are actively being upgraded to handle even more challenging data.

    Successful applicants will join the Department of Biological Sciences with over 60 full-time faculty members having diverse research expertise and over 300 graduate students from 19 countries. Facilities and research support are world-class and the university (www.nus.edu.sg) and department are internationally highly regarded.

    The university offers internationally competitive salary packages in Singapore’s low tax environment. The Department is committed to the achievement of excellence and diversity among its faculty, and female and minority candidates are encouraged to apply for the position.

    Interested, strong candidates with PhD and postdoctoral experience should forward a letter of intent describing their career goals, research plans, teaching interests, curriculum vitae and provide the names for at least five academic referees. Please send the application materials to:

    Chair, Structural Biology Search Committee (c/o Ms. Lisa Lau)
    Department of Biological Sciences
    National University of Singapore
    14 Science Drive 4
    Singapore 117543
    Fax: (65) 6779 5671; Email: dbslaul@nus.edu.sg

    Closing date of application: 31 May 2016 (Search will continue until a suitable candidate is found)


    Research Assistant Position

    We are looking for a Research Assistant to join our lab to work on a project in angiogenesis and cancer. Candidate with BSc (Honors) or MSc degree and prior lab experience in molecular biology, cell biology or biochemistry is preferred. PhD candidate who has submitted his/her thesis and are in the transition stage for degree completion are welcome to apply.

    Details of the research project will be provided to shortlisted candidates during interview.

    Successful candidates can expect a competitive salary and benefit package.  Interested candidates are encouraged to send their CV and full contacts of at least three referees to:

    Prof. Ruowen Ge, Department of Biological Sciences, National University of Singapore, Singapore, 119260. Email: dbsgerw@nus.edu.sg;

    For more information about our lab and research, please visit:
    Department of Biological Sciences faculty web: www.dbs.edu.nus.sg/Staff/ge.html;
    Molecular Angiogenesis lab web: http://staff.science.nus.edu.sg/~ruowenge/index.html.


    Research Fellow and Research Assistant

    To join our Ministry of Education Tier-3 project on “Saliva-assisted transmission of pathogenic viruses by blood-feeding arthropods in the Department of Biological Sciences/Duke-NUS.  This is an integrated, multi-disciplinary, comprehensive project to identify transmission enhancing proteins (TEPs) from vector saliva that play a critical role for Dengue (DENV) and Chikungunya (CHIKV) viruses. We aim to understand the biology of transmission, infection, and virulence of these viruses. This project will provide a strong foundation for developing novel strategies for combating other vector-borne diseases. The specific aims of this project are:

  • Identification of salivary proteins of Aedes aegypti mosquito that enhance transmission of dengue and chikungunya viruses
  • Understanding the roles of these salivary proteins and viruses with emphasis on transmission and vector competence and selectivity
  • Evaluation of vaccine candidate proteins in human cell lines and transgenic mouse models
  • Structure, function and mechanism of novel bioactive proteins from mosquito saliva

  • Candidates with an extreme interest in scientific research and a curious mind are invited to apply. Those with demonstration of strong experimental skills have advantages. Appointments will be made on 1 year contract basis in the first instance, with the possibility of extension up to 4 years.

    Purpose of the post
    The Research Assistants (RA) will be responsible to, and work closely with, the Principal Investigator and team members to ensure the successful completion of the experiments related to the above mentioned objectives. Research Fellows (RF) will lead the experiments and closely work with other members of the project towards accomplishing the objectives of this project.
     
    Main duties and responsibilities  
    Research Fellow (RF):
    (1) A PDF will have a combined expertise in structural and molecular biology. He/she will crystallize the selected salivary proteins and determine their structures. Further, he/she will conduct the structure based mutational and all functional studies.

    (2) A PDF will be responsible for NMR structural/functional study of salivary TEP.  Protein NMR technique allow study of protein dynamics and partially folded proteins.  Protein interaction study of salivary TEP with other human or viral targets will be studied by biolayer interferometry, ITC and site-directed mutagenesis.  This PDF should be an expert in protein NMR and capable of training other RA and PhD students.

    (3) A PDF would be needed to determine the role of TEPs in DENV infectivity of human cells.  The PDF would be responsible for primary cell isolation, culture and chemical differentiation into the various cellular subsets of relevance to DENV infection.  He/she would also lead the effort in designing experiments to identify differentially enriched proteins on the plasma membrane as well as to conduct function genomics study to demonstrate a function link between the putative plasma membrane and enhanced DENV entry. 

    (4) A PDF will be studying the role of TEPs in in vitro human cell cultures in order to decipher if YEPs can alter plasma membrane receptors and cytoplasmic proteins that favour CHIKV infection. To complement the in vitro cellular studies, the effect of selected candidate TEPs will also be evaluated in mouse models to define the immune responses. 

    (5) This PDF will be responsible of transcriptomes and proteomes of saliva/salivary gland extracts of two species mosquitoes that are either infected (with dengue and Chikungunya viruses) or uninfected. The work involves mRNA preparations, cDNA preparations, NextGenSequencing, assembly, and analyses of transcriptomes as well as MS/MS studies and bottom-up proteomics. PDF is involved in performing quantitative PCRs and quantitative proteomics. This PDF should be capable of training Research Assistant and PhD students.
    (6) This PDF will be responsible studying pharmacological function of saliva proteins. PDF will work on anticoagulant, antiplatelet, vasodilatory and immune suppressor activities of saliva proteins. This PDF will express a number of saliva proteins to evaluate their function. This PDF should be capable of training other Research Assistant and PhD students.

    Research Assistant (RA):
    (1) A RA will carry out the cloning, expression, purification, characterization and crystallization of various mosquito salivary proteins. Besides prepare the buffers, media and other reagents. This RA will closely work with the PDF and the PhD student.

    (2) A RA will help the PDF in cloning, expression, isotope labeling and purification of salivary TEP and its mutants for NMR structural and functional study.  He/she will also aid in the purchase of consumables and daily operation laboratory facilities.

    (3) A RA will study the function of salivary proteins regulated during virus infection. Using molecular biology, cell culture, microscopy and histology techniques, he/she will decipher the role of specific proteins on virus replication within the mosquitoes.

    (4) A RA will be in charge of overexpression, purification and robotic (Phoenix and Mosquitoe) crystallization assays of bioactive proteins and mosquito salivary proteins. Initial small scale screening will be performed by the production platform at NTU. In parallel, the RA will also produce labelled protein for NMR studies.

    (5) A RA will be responsible for growing and maintaining stocks of cells and viruses, performing virus and antibody titration (plaque assay, PRNT) as well as cytokine measurements (ELISAs) from cell supernatants and mouse samples. 
    (6) A RA will be responsible for expression of mosquito salivary proteins using eukaryotic systems for structural and functional studies.

    Qualifications  
    The applicant should have the following qualification and experience: 

    Research Fellow (RF, postdoctoral fellow):  Candidate with PhD degree and prior research experience in molecular biology, cell biology, structural biology, biochemistry or relevant area is required. Prior experience in the related areas of the objectives is a plus.

    Research Assistant (RA): Candidate with BSc (Honors) or MSc degree and prior lab experience in molecular biology, structural biology, cell biology, biochemistry or relevant area is preferred.

    Remuneration will be commensurate with the candidate’s qualifications and experience. Informal enquiries are welcome and should be made to Prof Henry Mok, Department of Biological Sciences, National University of Singapore, Email dbsmokh@nus.edu.sg
     
    Formal application
    Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of three referees by 7th April 2016 to:

    Prof. R. Manjunatha Kini, Department of Biological Sciences, National University of Singapore, Singapore, 119260. Email: dbskinim@nus.edu.sg

    (Or)

    Prof Eng Eong Ooi, Duke-NUS Medical School, Program in Emerging Infectious Diseases
    8 College Road, Singapore 169857. Email: engeong.ooi@duke-nus.edu.sg

    Only shortlisted candidates will be notified.


    Research Assistant

    The National University of Singapore invites applications for Research Assistant in Prof R Manjunatha Kini’s laboratory in the Department of Biological Sciences. Our laboratory is interested in the development of anticoagulant therapeutics from snake venom and tick saliva. Some examples of what we do can be found here:
    http://www.science.nus.edu.sg/research-highlights/1555-tapping-nature-s-medicine-cabinet-to-develop-anticoagulant-drug
    This appointment will be made on a 2 years contract basis in the first instance.

    Purpose of the post
    The Research Assistant (RA) will be responsible to, and work closely with, the Principal Investigator and study team members.
     
    Main duties and responsibilities  
    The applicant is expected to be involved in:

    1. Handling and processing of blood samples from healthy human volunteers
    2. Animal (mainly rodents) handlings and surgeries (thrombosis models)
    3. Recombinant protein expression and purification
    4. Solid phase peptide synthesis

    Qualifications  
    The applicant should: 

    1. Have a first degree with good results or holds a Master’s degree in life sciences, pharmacology, biochemistry, molecular biology, cell biology or other fields related/relevant to the position
    2. Laboratory/research experience in biochemistry, molecular biology is essential
    3. Prior experience in handling and surgery of animals is preferred

    Remuneration will be commensurate with the candidate’s qualifications and experience.
     
    Formal application: Please submit your application by email, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of 2 referees) by 1st April 2016 to:

    Dr. Koh Cho Yeow
    Email: choyeow@nus.edu.sg

    Only shortlisted candidates will be notified

    Research assistant in statistical optics for electron microscopy

    Fast electron detectors are rapidly changing electron microscopy. These detectors allow probabilistic imaging of very many noisy, incomplete, chance observations that are then statistically classified and interpreted. This mode of imaging has enabled unprecedented high resolution imaging of dynamical and heterogeneous systems. 

    The Centre for Bio-imaging Sciences at the National University of Singapore is one of the few places in the world that develops new algorithmic approaches in such probabilistic electron microscopy. We are looking for motivated, aspiring scientists who would like to join us in developing this emerging field of statistical electron microscopy. 

    Specific job description. Candidates must be willing to:

    1. learn/implement computer vision and statistical algorithms to electron microscopy;
    2. learn/implement machine learning algorithms (e.g. Naive Bayes, simple clustering, factor analyses, etc) for high resolution robust imaging;
    3. learn/implement highly parallelized programs (e.g. for GPGPUs, or the Intel MIC architecture);
    4. learn/implement numerical simulations of high-resolution imaging;
    5. collect and analyze large quantities of electron microscopy data.

    Terms of employment:
    This contract position, which will be renewed annually upon good performance, comes with a competitive salary and benefits package.

    Start date:
    Negotiable, but preferably May/Jun 2016. 

    Email the following to duaneloh@nus.edu.sg:

    1. Complete resume (including a full publication list, if applicable)  
    2. and three letters of recommendations for this position,
    3. any listing of a public code repository (e.g.  GitHub, bitbucket).

    Shortlisted candidates will be contacted for interviews.

    Application Requirements:

    •        Strong Bachelor’s or Master’s degree in either Physics, Applied Math, Computer Science, and/or Electrical Engineering.
    •        Familiar with the Unix Programming Environment.
    •        Proficient in Scientific Computing (C/C++/Python preferred).
    •        Good organization skills.
    •        Email us one typo in this advertisement.
    •        Strong mathematical foundation: calculus, probability and statistics, and linear algebra. 
    •        Strong ability to communicate and write in English.
    •        Strong ability to learn and work independently and also in a team.  

    Advantageous to have:

    •       Strong foundation in Optics and Electromagnetism (at the level of Hecht and Griffiths respectively).
    •       Strong foundation in methods commonly used in Data Science and/or Computer Vison.
    •       Experienced in programming for GPGPUs or the Intel MIC architecture.
    •       Familiar with parallel programming frameworks (e.g. PThreads, OpenMP, MPI, OpenACC, OpenCL, etc..).
    •       Strong foundation in the statistical treatment of experimental data (at the level of J.R.Taylor).
    •       Familiar with the Numerical Recipes: the Art of Scientific Programming (Press, Teukolsky, Vetterling, Flannery).


     

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