Department of Biological Science
National University of Singapore
14 Science Drive 4
Stomatal development, environmental signaling, transcriptional regulation, plant cell and developmental biology
Environment plays a key role in influencing how living organisms grow and develop. Our research aims at understanding the mechanism of this influence at the cellular level, using stomatal guard cells in plants as a model system. We employ a multidisciplinary approach, from cell biology to biochemistry, genetics to genomics, to decipher the environmental signaling network that controls the development of guard cells. Besides its values in fundamental research, the study of guard cells, which directly affect photosynthetic capacity and water usage, shall help guide efforts in crop improvement in the changing climate.
Lau OS† and Bergmann DC†. (2015) MOBE-ChIP: a large-scale chromatin immunoprecipitation assay for cell type-specific studies. Plant Journal 84:443-50. (†co-corresponding authors)
Lau OS, Davies KA, Chang J, Adrian J, Rowe MH, Ballenger CE and Bergmann DC. (2014) Direct roles of SPEECHLESS in the specification of stomatal self-renewing cells. Science 345:1605-09.
Matos JL*, Lau OS*, Hachez C*, Cruz-Ramírez A, Scheres B and Bergmann DC. (2014) Irreversible fate commitment upon exit from stem-cell-like divisions in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. eLife 3:e03271. (*co-first authors)
Lau OS and Bergmann DC. (2012) Stomatal development: a plant's perspective on cell polarity, cell fate transitions and intercellular communication. Development 39:3683-92.
Lau OS and Deng XW. (2012) The photomorphogenic repressors COP1 and DET1: 20 years later. Trends in Plant Science 17:584-93.
Lau OS, Huang X, Charron JB, Lee JH, Li G and Deng XW. (2011) Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock. Molecular Cell 43:703-12.
Lau OS and Deng XW. (2010) Plant hormone signaling lightens up: integrators of light and hormones. Current Opinion in Plant Biology 13:571-7.
Lau OS, Ng WK, Chan WL, Chang SP and Sun SSM. (2010) Production of the 42-kDa Plasmodium falciparum merozoite surface protein 1, a leading malaria vaccine antigen, in Arabidopsis thaliana seeds. Plant Biotechnology Journal 8:994-1004.
Lau OS and Sun SSM. (2009) Plant seeds as bioreactors for recombinant protein production. Biotechnology Advances 27:1015-22.
Lau OS and Deng XW. (2009) Effect of Arabidopsis COP10 ubiquitin E2 enhancement activity across E2 families and functional conservation among its canonical homologs. Biochemical Journal 418:683-90.
Jiao Y, Lau OS and Deng XW. (2007) Light-regulated transcriptional networks in higher plants. Nature Reviews Genetics 8:217-30.