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Curriculum
Vitae |
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Ge Ruowen
(Associate Professor and Deputy Head)
Contact
Information:
Department of Biological Sciences
National University of Singapore
Blk
S2, 05-04
Science
Drive 4
Singapore 117543
Tel: 65167879
Fax: 67792486
email:
dbsgerw@nus.edu.sg |
PhD
(Univ. of Pennsylvania)
Research interests:
Tumor
angiogenesis; liver organogenesis and embryonic angiogenesis
in zebrafish; anti-angiogenic cancer therapy
Current
projects:
Embryonic
angiogenesis and liver organogenesis in zebrafish:
Understanding
angiogenesis, the formation of new blood vessels, is very important
for cardiovascular biology and medicine. Angiogenesis is essential
for all tissue formation and growth. We use zebrafish as a model
organism to study embryonic angiogenesis and liver development.
- Role
of growth factors in zebrafish liver formation and angiogenesis
including Vascular Endothelial Growth Factor (VEGF), Hepatocyte
Growth Factor (HGF) as well as a novel liver growth factor
Hepatopoietin/Augmenter of Liver Regeneration.
- Histone
deacetylases (HDACs) in zebrafish angiogenesis and liver formation.
Tumor
angiogenesis:
Angiogenesis
is essential for tumor growth and metastasis. Anti-angiogenesis
is an alternative anti-cancer therapy that holds great promise.
We use mouse and rat tumor models to study tumor angiogenesis and
develop novel anti-angiogenic molecules for further drug development.
- Characterization
of the molecular differences between endothelial cells in normal
liver and liver cancer using a rat Hepatocellular Carcinoma
(HCC) model.
- Identification
of novel anti-angiogenic proteins and study their mechanisms
of action.
- Identification
of novel genes regulating angiogenesis.
Selected
recent publications:
-
Fan,
H., K.N. Sulochana, Y-S Chong and R. Ge. Decorin Derived
Antiangiogenic Peptide LRR5 Inhibits Endothelial Cell Migration
By Interfering With VEGF-Stimulated NO Release. Int.
J. Biochem. Cell Biol., in press, 2008.
-
Sharghi-Namini,
S., H. Fan, K.N. Sulochana, P. Potturi, W. Xiang, Y-S Chong,
Z. Wang, H. Yang, R. Ge. The first but not the second
thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis
inhibitor. Biochem.
Biophy. Res. Comm. 371:215-9, 2008.
-
Farooq,
M., K.N. Sulochana, X. Pan, J. To, D. Sheng, Z. Gong, R.
Ge. Histone deacetylase 3 (hdac3) is specifically required
for liver development in zebrafish. Dev.
Biol., 317:336-53, 2008.
-
K.N.
Sulochana and R. Ge. Developing Antiangiogenic Peptide
Drugs for Angiogenesis-Related Diseases. Curr.
Pharma. Des., 13:2074-86, 2007.
-
Ye,
L, KhH Haider, RS Tan, WC Toh, PK Law, WB Tan, LP Su, W Zhang, R
Ge, Y Zhang, Y T Lim and E K W Sim, 'Transplantation
of nanoparticle transfected skeletal myoblasts overexpressing
vascular endothelial growth factor 165 for cardiac repair'. Circulation 116(11
Suppl):I113-20, 2007.
-
Wang
Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M. Combining
pharmacological mobilization with intramyocardial delivery
of bone marrow cells over-expressing VEGF is more effective
for cardiac repair. J.
.Mol. Cell. Cardiol. 40:736-45,
2006.
-
K.
N. Sulochana, H. Fan, S. Jois, S. Vivekanandan, F. Sun,
R. M. Kini, and R. Ge. Peptides Derived From
Human Decorin Leucine Rich Repeat 5 Inhibit Angiogenesis. J.
Biol. Chem. 280: 27935-27948, 2005.
-
H.
Kh Haider, L.Ye, S. Jiang, R. Ge, P. K. Law, T. Chua,
P. Wong and E. K. W. Sim. Angiomyogenesis for cardiac repair
using human myoblasts as carriers of human vascular endothelial
growth factor. J. Mol. Med. 82:
539-49, 2004.
-
Sun,
F., D. Casse, J. A. Van Kan, R. Ge* and F. Watt. Geometric
Control of fibroblasts Growth on Proton Beam Micromachined
Scaffolds.Tissue Eng. 10, 267-272,
2004. *Corresponding author.
-
Niagara
MI, Haider HKh, Ye L, Koh VS, Lim YT, Poh KK, Ge R,
Sim EK. Autologous skeletal myoblasts transduced with a new
adenoviral bicistronic vector for treatment of hind limb ischemia. J.
Vasc. Surg. 40:774-85, 2004.
-
Shim,
W. S. N, M. Teh, A. Bapna, I, Kim, G-Y Koh, P. Mack and R.
Ge. Angiopoietin-1 Promotes Tumor Angiogenesis and Tumor
Vessel Plasticity ofHuman Cervical Cancer in Mice. Exp.
Cell Res. 279, 299-309, 2002.
-
Sim
EK, Zhang L, Shim WS, Lim YL, Ge R.Therapeutic Angiogenesis
for Coronary Artery Disease. J.
Card. Surg. 17, 350-354, 2002.
-
Liu
L, S.Chong, N. V. Balasubramaniyan, V. Korzh and R. Ge.
Platelet Derived Growth Factor Receptor Alpha (pdgfr-a)
Gene In Zebrafish Embryonic Development. Mech.
Dev. 116, 227-230, 2002.
-
Liang,
D., J. Chang, A. J. Chin, A. Smith, C. Kelly, Eric S. Weinberg
and R. Ge. The Role of Vascular Endothelial Growth
Factor (VEGF) in Vasculogenesis, Angiogenesis, and Hematopoiesis
in Zebrafish Development. Mech.
Dev. 108, 29-43, 2001.
-
Tan, D C-W.,
M. R. Kini., J. D. S. Seetharama, D. K-F Lim, L. Xin and R.
Ge. A Small Peptide Derived From Flt-1 (VEGFR-1) Functions
As An Angiogenic Inhibitor. FEBS
Lett. 494,150-156, 2001.
-
Shim, W S-N,
M. Teh, P. Mack and R. Ge. Inhibition Of Angiopoietin-1
Expression In Tumor Cells By An Antisense RNA Approach Inhibited
Xenograft Tumor Growth In Immunodeficient Mice. Int.
J. Cancer 94, 6-15, 2001.
-
Sleptsova-Friedrich,
I, Y. Li, A. Emelyanov, M. Ekker, V. Korzh and R. Ge.
Fgfr3 And Regionalization Of Anterior Neural Tube In Zebrafish. Mech.
Dev. 102, 213-217, 2001.
Patents:
-
Ge,
R and
R. M. Kini, Small Peptides With Potent Anti-Angiogenic Activities.
US patent No. 7,317,003, 2008.
-
Ge, R and R. M. Kini, Small Peptides with Potent Anti-Angiogenic Activities.
US patent No. 6,200,954, 2001.
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