Faculty Home

HAN Jin-Hua (Assistant Professor) Contact Information:  Dept of Biological Sciences National University of Singapore 14 Science Drive 4 Singapore 117543   Office location: S2-04-05A Tel: +65 6516-2694 Fax: +65 6779-2486 email: jinhuahan@nus.edu.sg

Education and Training:

Postdoctoral Associate: 1998-2000 Yale University
Ph.D. 1997 Washington University School of Medicine
B.S. 1991 Peking University

Recent Appointments:

• September 2004-present : Assistant Professor, National University of Singapore, Singapore
• July 2001-August 2004 : Research Scientist, Bioinformatics, Bayer Pharmaceutical Corp, USA\
• Nov 2000-June 2001 : Database Quality Assurance Manager, Genaissance Pharmaceuticals Inc., USA
• June-October, 2000 :Computational Molecular Biologist, Informatics, Genaissance Pharmaceuticals Inc., USA

Research Areas:

Computational biology, Bioinformatics, Gene expression profiling, DNA microarrays, Proteomics, Biomarkers, Disease mechanisms, Drug discovery.

The overall goal of our research program is to understand molecular mechanisms of human diseases by applying computational biology methods. We are developing integrative knowledge management platform that combines DNA sequences, protein domains, gene functional annotations and biological pathway information in an effort to address the needs of modern large-scale biology. Specifically, we are interested in developing analysis methods for mining expression profiling data derived from DNA microarrays and proteomics. On-going research projects in the lab include studies of acute myeloid leukemia (AML) and diabetes using systematic approach.

Award:

2002 Bayer Special Recognition Award

Selected Publications:

• Kong Y and Han JH. MicroRNA: biological and computational perspective. Genomics Proteomics Bioinformatics . 2005 May 3 (2):62-72.

• Chen CS, Lin Q, Tai Y, Hew CL, and Han JH . Molecular mechanisms of genistein in human Leukemia cells, a proteomics and DNA microarray approach .Proceedings AACR-NCI- EORTC International Conference Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications , 2005.

• Chen CS, Wong S, Tay BL, Shen J, Khan M, and Han JH . Naturally occurring tyrosine kinase inhibitor, Genistein, exerts distinct anti-leukemia mechanisms in AML and APL cells . European Journal of Cancer Supplement, ECCO13, 2005.

• Wong S, Low M, Shen J, Lin Q, Hew CL, Han JH, Khan M, and Chen CS . Genistein induces apoptosis in acute myeloid leukemia cells and affects Proteasome pathway by proteomic analysis. Proceedings of the American Association for Cancer Research, Volume 46, 555a, 2005.

• Stephens JC, Schneider J, Tanguay DA, Choi J, Acharya T, Stanley SE, Jiang R, Messer CJ, Chew A, Han JH, Duan J, Carr JL, Lee MS, Koshy B, Kumar AM, Zhang G, Newell WR, Windemuth A, Xu C, Kalbfleisch TS, Shaner SL, Arnold K, Schulz V, Drysdale CM, Nandabalan K, Judson RS, Ruano G, and Vovis GF . Haplotype Variation and Linkage Disequilibrium in 313 Human Genes. Science 2001 Jul 20; 293 (5529): 489-493

• Han JH , Lee S, Tan Y and Hashimoto C. Gastrulation Defective is a Serine Protease Involved in Activating the Receptor Toll to Polarize the Drosohpila Embryo. Proc Natl Acad Sci USA .2000 Aug 1; 97 (16): 9093-7

• Han JH , Zhang H, and Hashimoto C. A Novel Drosophila Serpin that Inhibits Serine Proteases. FEBS Letters , 2000, 468: 194-198

• Han JH , and Tollefsen DM. Ligand Binding to Thrombin Exosite II Induces Dissociation of the Thrombin-Heparin Cofactor II (L444R) Complex. Biochemistry, 1998, 37(9): 3203-3209.

• Han JH, Cote HCF, and Tollefsen DM. Inhibition of Meizothrombin and Meizothrombin (desF1) by Heparin Cofactor II. J. Biol. Chem., 1997, 272 (45): 28660-28665.

• Han, JH , Van Deerlin, VMD, and Tollefsen, DM. Heparin Facilitates Dissociation of Complexes between Thrombin and A Reactive Site Mutant (L444R) of Heparin Cofactor II. J. Biol. Chem ., 1997, 272(13): 8243-8249.