Lam Siew Hong (Lecturer) Contact Information: Department of Biological Sciences National University of Singapore 14 Science Drive 4 Singapore 117543 Email: dbslsh@nus.edu.sg

PhD NUS

Research interests:

Environmental Health Genomics, Disease Modeling, Toxicogenomics, and Systems Biology.

Selected recent publications

1. Lam SH, Mathavan S, Gong Z (2009). Zebrafish Spotted-Microarray for Genome-Wide Expression Profiling Experiments (Part I): Array Printing and Hybridization. Methods in Molecular Biology. Humana Press Totowa, New Jersey. 546:175-195.

2. Lam SH, Murthy KR, Gong Z (2009). Zebrafish Spotted-Microarray for Genome-Wide Expression Profiling Experiments (Part II): Data Acquisition and Analysis. Methods in Molecular Biology. Humana Press Totowa, New Jersey. 546:197-226.

3. Lam SH, Mathavan S, Tong Y, Li H, Murthy KR, Wu YL, Vega VB, Liu ET, Gong Z (2008). Zebrafish Whole-Adult-Organism Chemogenomics for Large-Scale Predictive and Discovery Chemical Biology. PLoS Genetics 4(7):e1000121. 

4. Lam SH, Winata CL, Tong Y, Korzh L, Korzh V, Spitsbergen J, Sinnakarupan M, Miller LD, Liu ET, Gong Z (2006). Trancriptome Kinetics of Arsenic-induced Adaptive Response in Zebrafish Liver. Physiological Genomics27(3):351-61 .

5. Lam SH, Gong Z (2006). Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell Cycle. 5(6):573-7.

6. Lam SH, Wu YL, Vega VB, Miller LD, Spitsbergen J, Tong Y, Zhan H, Govindarajan KR, Lee S, Mathavan S, Murthy KR, Buhler DR, Liu ET, Gong Z (2006). Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol. 24(1):73-5.

7. Zeng Z, Shan T, Tong Y, Lam SH, Gong Z (2005). Development of estrogen-responsive transgenic medaka for environmental monitoring of endocrine disrupters. Environmental Science and Technology 39(22):9001-8.

8. Mathavan S, Lee SG, Mak A, Miller LD, Murthy KR, Govindarajan KR, Tong Y, Wu YL, Lam SH, Yang H, Ruan Y, Korzh V, Gong Z, Liu ET, Lufkin T (2005). Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genetics 1(2):260-76.

9. Lam SH, Sin YM, Gong Z, Lam TJ (2005). Effects of Thyroid Hormone on the Development of Immune System in Zebrafish. General and Comparative Endocrinology 142(3):325-35.

10. Tong Y, Shan T, Poh YK, Yan T, Wang H, Lam SH, Gong Z (2004). Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol. Gene 328:25-36.

11. Lam SH, Chua HL, Gong Z, Lam TJ, Sin YM (2004). Development and Maturation of the Immune System in Zebrafish, Danio rerio: A Gene Expression Profiling, In Situ Hybridization and Immunological Study. Developmental and Comparative Immunology 28:9-28.

12. Lam SH, Chua HL, Gong Z, Wen Z, Lam TJ, Sin YM. (2002). Morphologic Transformation of the Thymus in Developing Zebrafish. Developmental Dynamics 225:87-94.

Textbook Chapter

• Lam SH, Gong Z. Model Organisms for Human Disorders: Fish. In Human Genetics - Principles and Approaches - 4th Ed. (Eds. F. Vogel, A.G. Motulsky, S Antonarakis and M. Speicher). Springer Verlag,Heidelberg (In Press).