Back

Lin Qingsong Assistant Professor Department of Biological Sciences Contact Information: Department of Biological Sciences National University of Singapore 14 Science Drive 4 Singapore 117543 Tel: 65167769 Fax:67792486 email: dbslinqs@nus.edu.sg

Academic qualification :

2002 Ph. D. University of Toronto, Canada (major in Clinical Biochemistry)

1994 M. Sc. Xiamen University, China (major in Enzymology)

1991 B. SC. Xiamen University, China (major in Biochemistry)

Research Interests

• Proteomics and mass spectrometry
• Cancer biomarker discovery and cancer biology

Selected Publications:

1. Zubaidah R. M., Tan G. S., Tan S. B., Lim S. G., Lin Q., and Chung M. C. (2008) 2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis, Proteomics, 8(23-24): 5086-5096.

2. Lee Y. H., Chung M. C., Lin Q., Boelsterli U. A. (2008) Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: Two-stage oxidative injury, Toxicol. Appl. Pharmacol., 231(1): 43-51

3. Tong A.*, Wu L.*, Lin Q.*, Lau Q. C., Zhao X., Li J., Chen P., Chen L., Tang H., Huang C., Wei Y. Q. (2008 May) Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model, Proteomics, 8(10): 2012-23. (*equal contribution).

4. Tan H. T., Tan S., Lin Q., Lim T. K., Hew C. L., and Chung M. C. (2008 Jun) Quantitative and temporal proteome analysis of butyrate-treated colorectal cancer cells, Mol. Cell. Proteomics, 7(6): 1174-85.

5. Lee Y. H., Boelsterli U. A., Lin Q., and Chung M. C. M. (2008 Feb) Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/- mice, an animal model of discreet mitochondrial oxidative stress, Proteomics, 8(3): 555-568.

6. Chen Y., Choong L. Y., Lin Q., Philps R., Wong C. H., Ang B. K., Loh M. C. S., Hew C. L., Shah N., Druker B. J., Chong P. K. and Lim Y. P. (2007 Dec) Differential expression of novel tyrosine kinase substrates during breast cancer development, Mol. Cell. Proteomics, 6(12): 2072-2087.

7. Wu J.*, Lin Q.*, Lim T. K., Liu T., Zhuang Y., and Hew C. L. (2007 Nov) White spot syndrome virus proteins and differentially expressed cellular proteins identified in shrimp epithelium by shotgun proteomics and cleavable isotope-coded affinity tag, J. Viol., 81(21):11681-9 (*equal contribution).

8. Li Z.*, Lin Q.*, Chen J.*, Lim T. K., and Hew C. L. (2007 Sept) Shotgun Identification of Structural Proteome of Shrimp White Spot Syndrome Virus and iTRAQ Differentiation of Envelope and Nucleocapsid Subproteomes, Mol. Cell. Proteomics, 6(9):1609-1620 (*equal contribution)

9. Zhang H., Lin Q., Ponnusamy S., Kothandaraman N, Lim T. K., Zhao C., Hon S. K., Arijit B., Rauff M., Hew C. L., Chung M. C. M., Joshi S. B. and Choolani M. (2007 May) Differential recovery of membrane proteins after extraction by aqueous methanol and trifluoroethanol, Proteomics, 7:1654-1663.

10. Bi X. Z.*, Lin Q.*, Foo, J. T. W.*, Joshi S., You T., Shen H. M., Ong C. N., Cheah P. Y., Eu K. W. and Hew C. L (2006 Jun) Proteomics analysis of colorectal cancer reveals alterations in metabolic pathways – mechanism of tumorigenesis, Mol. Cell. Proteomics, 5(6): 1119-1130 (*equal contribution)

11. Tay T. L., Lin Q., Seow T. K., Tan K. H., Hew C. L., and Gong Z. (2006 May)  Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio.  Proteomics, 6: 3176-3188.

12. Song W. J.*, Lin Q.*, Joshi S., Lim T. K., and Hew C. L. (2006 Feb) Proteomics Studies of the Singapore Grouper Iridovirus. Mol. Cell. Proteomics, 5.2: 256-264 (*equal contribution).

13. Lo S. L., You T., Lin Q., Joshi S., Chung M. C. M., and Hew C. L. (2006 Mar) SPLASH: Systematic Proteomics Laboratory Analysis and Storage Hub.  Proteomics, 6(6): 1758-1769.

14. Huang, C., Zhang, X., Lin, Q., Xu, X., Hu, Z., and Hew, C. L.  (2002) Proteomic analysis of shrimp white spot syndrome viral proteins and characterization of a novel envelope protein VP466. Mol. Cell. Proteomics 1, 223-231.