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NG
Huck Hui
(Assistant
Professor)
Contact Information:
Dept of Biological
Sciences
National University of Singapore
Science Drive 4
Singapore 117543
Tel: 6478 8145
Fax:6478 9004
email: dbsnghh@nus.edu.sg
Joint appointment : Department of Biological Sciences and
Genome Institute of Singapore
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Research Areas
Gene Regulation, Genomics, Chromatin
Education
B.Sc (Honours 1st class) National University of Singapore (1992-1996)
Advisor: Eng Chong Pua and Ben Li
PhD. University of Edinburgh (1996-1999)
Advisor: Adrian Bird
Professional Appointments
Damon Runyon Cancer Research Fund Postdoctoral fellow
Harvard Medical School (2000-2003)
Advisor: Kevin Struhl
Joint appointee (2003-present):
Assistant Professor, Department of Biological Sciences, NUS Group
Leader
Genome Institute of Singapore, A*STAR
Honors and Awards
Dean's List (NUS) 92/93
Dean's List (NUS) 93/94
Dean's List (NUS) 94/95
Undergraduate Science Research Programme 92/93
Undergraduate Science Research Programme 93/94
Institute of Molecular and Cell Biology Summer Research Studentship
94/95 Lijen Industrial Development Medal 95-96 (best Honours project)
Darwin Trust of Edinburgh Scholarship 96/99 (PhD scholarship)
Damon Runyon-Walter Winchell Postdoctoral fellowship 2000-2003
Human Frontier Science Program Long-term fellowship (declined)
Leukemia Society of America Postdoctoral fellowship (declined)
Publications
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Ng, HH., Zhang, Y., Hendrich, B., Johnson, CA., Turner, BM., Erdjument-Bromage, H., Tempst, P., Reinberg, D., Bird, A. (1999). The methyl-CpG binding protein MBD2 is a transcriptional repressor belonging to the MeCP1 fraction of histone deacetylase complexes. Nature Genetics . 23, 58-61.
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Ng, HH., Robert, F., Young, RA., Struhl, K. (2003). Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Molecular Cell. 11, 709-719.
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Fortunel, N.*, Otu, H.*, Ng, HH.*, Chen, J., Mu, X., Chevassut, T., Li, X., Joseph M., Bailey C., Hatzfeld, J., Usta, F., Vega, VB., Long, PM., Towia Liberman, T., Lim, B. (2003). Comment on 'Stemness: Transcriptional Profiling of Embryonic and Adult Stem Cells' and 'A Stem Cell Molecular Signature'. Science. 302, 393. * equal contribution
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Kho, PS., Wang, Z., Zhuang, L., Li Y., Chew, JL., Ng, HH., Liu, ET., Yu Q. (2004). p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis. J. Biol. Chem. 279(20):21183-92.
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Chew, JL., Loh, YH., Zhang, W., Chen, X., Tam, WL., Yeap, LS., Li, P., Ang, YS., Lim, B., Robson, P., Ng, HH@. (2005). Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Molecular & Cellular Biology. 25(14):6031-46.
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Radda, D., Chew, JL., Lim, LH., Loh, YH., Wang, B., Ng, HH@., Robson, P. (2005). Transcriptional regulation of Nanog by Oct4 and Sox2. Journal of Biological Chemistry. 280(26):24731-7.
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Wei, CL., Wu, Q., Vega, V., Chiu, KP., Ng, P., Zhang, T., Shahab, A., Ridwan, A., Fu, Y., Weng, Z., Liu, JJ., Kuznetsov, VA., Sung, K., Lim, B., Miller, LD., Liu, ET., Yu, W., Ng, HH@., Ruan, YJ. (2006). A Global Mapping of p53 Transcription Factor Binding Sites in the Human Genome. Cell. 124(1):207-219.
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Wang, X., Kua, HY., Hu, Y., Guo, K., Zeng, Q., Wu, Q., Ng, HH., Karsenty, G. , de Crombrugghe, B. , Yeh, J., Li, B. (2006). p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis and bone remodeling. Journal of Cell Biology. 172(1):115-25.
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Loh, YH., Wu, Q., Chew, JL., Vega, V., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong KY., Sung, K., Lee, CW., Zhao XD., Chiu, KP., Lipovich, L., Kuznetsov, VA., Robson, P., Stanton, LW., Wei, CL., Ruan, YJ., Lim, B., Ng, HH@ (2006). The Oct4 and Nanog transcription network that regulates pluripotency in mouse embryonic stem cells. Nature Genetics. 38(4):431-40.
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Wu, Q., Chen, X., Zhang, J., Loh, YH., Low, TY, Zhang, W., Zhang, W., Sze, S., Lim, B., Ng,
HH@. (2006). Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J. Biol. Chem. (Accelerated Publication). In press.
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