Department of Biological Science
National University of Singapore
14 Science Drive 4
Ph.D. in Biology from Dartmouth College, Hanover, New Hampshire.
Mechanobiology of cells and tissues, dynamics of nano-scale water, biomaging sciences.
The main thrust of research in the last decade has been on the structure and mechanisms that generate force. In current research, the lab is studying two main problems: epithelial cell migration on 2D surfaces and mesenchymal/amoeboid cell migration in 3D matrices. We are studying how epithelial cells move in cell culture and in vivo and are characterizing the mechanical factors that control movement and the type of motility.
Our interests in imaging arose from studies on the dynamics of actin bundles and cell adhesions. From its origin in the WI Keck Microscopy Facility and the WI-MIT BioImaging Center at MIT, the scale and scope of bioimaging has grown and moved in 2010 to the NUS Centre for BioImaging Sciences. With newly renovated labs opened in 2011, CBIS is devoted to development and application of state-of-art TEM and light microscopy methods to problems in molecular, cell, and tissue mechanobiology.
Recent research in the group share a common theme in dynamics: imaging of tissue formation and dynamics in developing Zebrafish embryos, imaging protein in room temperature water by real-time TEM, trapping nanoparticles in an electron trap, and formation and dynamics of nm-diameter water droplets.