Genetics, Cell Biology, Developmental Biology, Zebrafish, Mouse, Human Genetics, Cilia, Myogenesis, Hedgehog signaling
Sudipto Roy was educated at some of the most distinguished institutions in India. After schooling from Goethals Memorial in Kurseong, Darjeeling, and La Martiniere for Boys in Calcutta, he graduated with a first class first (honours) in zoology from Presidency College in Calcutta in 1991, and again secured the first position during his M.Sc. studies at the Jawaharlal Nehru University, New Delhi, in 1993. He then moved to the National Centre for Biological Sciences in Bangalore, where he obtained a Ph.D. in developmental genetics, studying the cellular and genetic basis of muscle and neuronal development in the fruit fly, Drosophila, with K. VijayRaghavan. During this period, he travelled to Brandeis University in the US and to Cambridge University, England, as a visiting graduate student. He began post-doctoral studies with Philip Ingham at the Centre for Developmental and Biomedical Genetics at the University of Sheffield, England, in 1998, where he initiated research into vertebrate development using the zebrafish embryo. Dr. Roy has been the recipient of several awards and fellowships from international organizations that include the Company of Biologists (UK), the Wellcome Trust (UK), the Human Frontiers Science Program (HFSP) and the European Molecular Biology Organization (EMBO). In 2002, he was honoured with the prestigious Indian National Science Academy Young Scientist Medal by the President of India, the late Dr. Abdul Kalam. In the same year, he joined the Institute of Molecular and Cell Biology in Singapore as a Young Investigator, and was a Principal Investigator (Assistant Professor) from 2003-2008.
Dr. Roy is currently a Senior Principal Investigator, and is an adjunct Associate Professor with the Department of Biological Sciences and the Department of Paediatrics of the National University of Singapore, and was visiting Professor on sabbatical with the National Institute of Biomedical Genomics, Kalyani, India (Jul-Dec, 2017). Over the years, his science has made important contributions to our understanding of many aspects of developmental biology that include how hox genes regulate muscle patterning in flies, the discovery of blimp1 as a selector gene for zebrafish slow-twitch muscle, the genetic pathways regulating vertebrate myoblast fusion, the identification of Kif7 and Dzip1 as ciliary proteins in the vertebrate Hedgehog pathway and elucidation of the master regulatory roles of the FoxJ1, Gmnc and Mcidas transcription factors in programming ciliary differentiation. His current research utilizes the zebrafish and the mouse to study the mechanistic basis of human diseases, notably those arising from dysfunction of cilia and flagella. In 2012, he was awarded the STAR Employee Award from the Agency for Science, Technology and Research of Singapore (A*STAR) for his achievements and services to scientific research in Singapore. Recently, he has developed a liking for communicating science to the general public through writing, and in 2015 won a merit award at the inaugural Asian Scientist Writing Prize competition. In 2016, he was conferred the first distinguished alumnus award on the occasion of the silver jubilee celebrations of the National Centre for Biological Sciences, India.
Roy, S. and VijayRaghavan, K. (2012). Developmental Biology: Taking flight. Current Biology 22, R63-65 (Review article).
Vij, S., Rink, J. C., Ho, H. K., Babu, D., Eitel, M., Narasimhan, V., Tiku, V., Westbrook, J., Schierwater, B., and Roy, S. (2012). Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. PLoS Genetics 8, e1003019.
Babu, D. and Roy, S. (2013). Left-right asymmetry: Cilia stir up new surprizes in the node. Open Biology 3, 130052 (Review article).
Choksi, S. P., Lauter, G., Swoboda, P.*, and Roy, S.* (2014). Switching on cilia: transcriptional networks regulating ciliogenesis. Development 141, 1427-1441
Choksi, S. P.*, Babu, D., Lau, D., Yu, X., and Roy, S.* (2014). Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development 141, 3410-3419 (Cover issue).
Lu, H., Toh, M. T., Narasimhan, V., Thamilselvam, S. K., Choksi, S. P., and Roy, S. (2015). A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Developmental Biology 397, 225-236 (Cover issue).
Narasimhan, V., Hjeij, R., Vij, S., Loges, N. T., Wallmeier, J., Koerner-Rettberg, C., Werner, C., Thamilselvam, S. K., Boey, A., Choksi, S. P., Pennekamp, P., Roy, S.* and Omran, H.* (2015). Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer. Human Mutation 36, 307-318.
Narasimhan, V. and Roy, S. (2015). Cilia: organelles at heart of heart disease. Current Biology 25, R559-562 (Review article).
Zhou, F. and Roy, S. (2015). SnapShot: Motile cilia. Cell 162, 224 (Review article).
Boyd, P., Cunliffe, V. T., Roy, S.* and Wood, J.* (2015). Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): Implications for mental illness. Biology Open 4, 1336-1343.
Zhou, F., Narasimhan, V., Shboul, M., Chong, Y. L., Reversade, B., and Roy, S. (2015). Gmnc is a master regulator of the multiciliated cell differentiation program. Current Biology 25, 3267-3273.
Chen, Y., Chang, K. T., Lian, D. W., Lu H., Roy, S., Laksmi N. K., Low, Y., Krishnaswamy, G., Pierro, A., Ong, C. C. (2016). The role of ischemia in necrotizing enterocolitis. Journal of Pediatric Surgery 8, 1255-1261.
Zhang, W and Roy, S. (2016). The zebrafish fast myosin light chain mylpfa:H2B-GFP transgene is a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo. Gene Expression Patterns 20, 106-110.
Zhang, W and Roy, S. (2017). Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo. Developmental Biology 423, 24-33 (Cover issue).
Lu H., Rondón Galeano, M. C., Ott, E., Kaeslin, G., Kausalya, P. J., Kramer, C., Ortiz-Brüchle, N., Hilger, N., Metzis, V., Hiersche, M., Tay, S. Y., Tunningley, R., Vij, S., Courtney, A. D., Whittle, B., Wühl, E., Vester, U., Hartleben, B., Neuber, S., Frank, V., Little, M. H., Epting, D., Papathanasiou, P., Perkins, A. C., Hunziker, W., Gee, Y. H., Otto, E. A., Zerres, K., Hildebrandt, F., Roy, S.*, Wicking, C.*, and Bergmann, C*. (2016). Mutations in DZIP1L, which encodes a ciliary transition zone protein, cause autosomal recessive polycystic kidney disease. Nature Genetics 49, 1025-1034.
Windpassinger, C., Piard, J., Bonnard, C., Alfadhel, M., Lim, S., Bisteau, X., Blouin, S., Ali, N. B., Ng, A. Y. J., Lu, H., Tohari, S., Talib, S. Z. A., van Hul, N., Caldez, M. J., van Maldergem, L., Youssef, S., Coppola, V., de Bruin, A., Tessarollo, L., Choi, H., Rupp, V., Rötzer, K., Roschger, P., Klaushofer, K., Roy, S., Venkatesh, B., Ganger, R., Grill, F., Chehida, F. B., Altunoglu, U., Al Kaissi, A., Reversade, B., and Kaldis, P. (2017). Mutations in CDK10 in humans and mice cause severe growth retardation, spine malformation, and intellectual disabilities. American Journal of Human Genetics 101, 391-403.
Chong, Y. L., Zhang, Y., Zhou, F, and Roy, S. (2018). Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Developmental Biology 443, 165-172
Zhang, X., Jia, S., Chen, Z., Chong, Y. L., Xie, H., Feng, D.,
Wu, X., Song, D. Z., Roy, S., and Zhao, C. (2018). Cilia-driven cerebrospinal fluid flow directs expression of Urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics 50, 1666-1673.
Lu, H., Anujan, P., Zhou, F., Zhang, Y., Chong, Y. L., Bingle, C. D. and Roy, S. (2019). Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals. Development 146, pii: dev172643 (Cover issue).
Mukherjee, I., Roy, S.*, and Chakrabarti, S*. (2019). Identification of important effector proteins in the FOXJ1 transcriptional network associated with ciliogenesis and ciliary function. Frontiers in Genetics 10, 23. * Joint senior author