Kunchithapadam Swaminathan

Associate Professor

Contact Information:

Department of Biological Science
National University of Singapore
14 Science Drive 4
Singapore 117543

Curriculum Vitae

6516 7932
6779 2486

Academic Qualifications

7/1978-5/1981 B.Sc. (Physics with distinction) Madras Univ., India
8/1981-6/1983 M.Sc. (Physics with distinction) Madras Univ., India
1/1984-11/1989 Ph.D. in Crystallography - Indian Inst. of Technology, Bombay, India

Post-doctoral Training

11/1989 - 5/1995 Department of Chemistry, Univ. of Pennsylvania, Philadelphia, USA (with Prof. Donald Voet, the author of the famous Voet & Voet Biochemistry textbook)
5/1995 - 12/1997  The Wistar Institute, Philadelphia, USA (with Prof. Ronen Marmorstein)


Our lab focuses on two areas of research:

Experimental structural biology: We study the structural aspects of cell signaling and gene regulation in human diseases, mainly cancer and neurodegenerative diseases. In addition, we also undertake structure determination of selected membrane proteins that are involved in cell signaling and transportation.
Protein structures conform to evolutionary genetic changes. As these molecular level changes are responsible for disorders and diseases, clear understanding of the nature of diseases mandates precise structure determination of the related proteins. We use X-ray crystallography as the main tool to determine protein structures and follow by biophysical, biochemical and functional characterization, to address and answer major biological questions.

Computational biology: Recently we have initiated interest in computational biology, following my sabbatical attachment. We are planning to expand our focus on next generation sequencing and big data.