Our lab focuses on two areas of research:
Experimental structural biology: We study the structural aspects of cell signaling and gene regulation in human diseases, mainly cancer and neurodegenerative diseases. In addition, we also undertake structure determination of selected membrane proteins that are involved in cell signaling and transportation.
Protein structures conform to evolutionary genetic changes. As these molecular level changes are responsible for disorders and diseases, clear understanding of the nature of diseases mandates precise structure determination of the related proteins. We use X-ray crystallography as the main tool to determine protein structures and follow by biophysical, biochemical and functional characterization, to address and answer major biological questions.
Computational biology: Recently we have initiated interest in computational biology, following my sabbatical attachment. We are planning to expand our focus on next generation sequencing and big data.