Dept of Biological Sciences
National University of Singapore
Science Drive 4,
Room: S3-06-016516 7712
PhD, Goteborg, SWEDEN; BSc, Fudan, PRC
Immunotherapy against Cancer
Immunotherapies selectively activate the immune system in patients and have sparked a revolution in cancer treatment. The research focus of my laboratory is on the development of biological therapy approaches applicable to cancer immunotherapy. In recent several years, we have been working towards building platform technologies that support the development of novel immune cell-based therapeutics. Powerful cell generation, expansion, and modification technologies used in the production process for cancer immunotherapy have been established. Several new cellular therapeutics in the area of chimeric antigen receptor (CAR) adoptive immunotherapy and with potential for use against a broad range of cancers are under testing currently. We aim to make a contribution to the progress of translational medicine, translating discoveries in basic immunology into safe and effective therapeutic applications..
Zha S, Li Z, Chen C, Du Z, Tay JC, Wang S. Beta-2 microglobulin knockout K562 cell-based artificial antigen presenting cells for ex vivo expansion of T lymphocytes. Immunotherapy. 2019 Aug; 11(11):967-982.
Zeng J, Tang SY, Wang S. Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell. PLoS One. 2019 May 9; 14(5):e0216815.
Tan WK, Tay JCK, Zeng J, Zheng M, Wang S. Expansion of Gamma Delta T Cells – A Short Review on Bisphosphonate and K562-Based Methods. J Immunological Sci. (2018); 2(3): 6-12
Xiao L, Chen C, Li Z, Zhu S, Tay JC, Zhang X, Zha S, Zeng J, Tan WK, Liu X, Chng WJ, Wang S. Large-scale expansion of Vγ9Vδ2 T cells with engineered K562 feeder cells in G-Rex vessels and their use as chimeric antigen receptor-modified effector cells. Cytotherapy. 2018 Mar; 20(3):420-435.
Tay JC, Zha S, Wang S. Chimeric switch receptor: switching for improved adoptive T-cell therapy against cancers. Immunotherapy. 2017 Dec; 9(16):1339-1349.
Zeng J, Tang SY, Toh LL, Wang S. Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Dec 12; 9(6):1796-1812.
Ang WX, Li Z, Chi Z, Du SH, Chen C, Tay JC, Toh HC, Connolly JE, Xu XH, Wang S. Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis. Oncotarget. 2017 Feb 21; 8(8):13545-13559.
Du SH, Li Z, Chen C, Tan WK, Chi Z, Kwang TW, Xu XH, Wang S. Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy. PLoS One. 2016 Sep 6; 11(9):e0161820.
Ang WX, Zhao Y, Kwang T, Wu C, Chen C, Toh HC, Mahendran R, Esuvaranathan K, Wang S. Local Immune Stimulation by Intravesical Instillation of Baculovirus to Enable Bladder Cancer Therapy. Sci Rep. 2016 Jun 8; 6:27455.
Updated July 2019