Department of Biological Science
National University of Singapore
14 Science Drive 4
Functional Genomics; Plant Growth Regulation; Plant Physiology
The completion of the Arabidopsis genome sequence is a critical milestone of plant science. At current stage, a publicized goal is to clarify the function of all sequenced Arabidopsis genes. My interests are to investigate gene regulatory networks involved in the control of reproductive development and hormone signaling in Arabidopsis. Studies on Arabidopsis not only gain basic information on developmental mechanisms, but also provide useful information on classical breeding or genetic manipulation of economically important crops, such as orchid, rice and vegetables.
International refereed journals
Gong X, Shen L, Peng YZ, Gan Yi, Yu H (2017) DNA topoisomerase Iα affects the floral transition in Arabidopsis. Plant Physiology 173: 642-654.
Shen L, Liang Z, Gu X, Chen Y, Teo ZWN, Hou X, Cai WM, Dedon PC, Liu L, Yu H (2016) N6-methyladenosine RNA modification regulates shoot stem cell fate in Arabidopsis. Developmental Cell 38: 186-200.
Zhu Y, Liu L, Shen L, Yu H (2016) NaKR1 regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis. Nature Plants 2: 16075. DOI:10.1038/nplants.2016.75.
Xi W, Gong X, Yang Q, Yu H*, Liou YC* (2016) Pin1At regulates PIN1 polar localization and root gravitropism. Nature Communications 7: 10430. doi: 10.1038/ncomms10430 (*Co-corresponding author).
Chen M, Zhang B, Li C, Kulaveerasingam H, Chew FT, and Yu H (2015) TRANSPARENT TESTA GLABRA 1 regulates the accumulation of seed storage reserves in Arabidopsis. Plant Physiology 169: 391–402.
Yan Y, Shen L, Chen Y, Bao S, Thong Z, Yu H (2014) A MYB-domain protein EFM mediates flowering responses to environmental cues in Arabidopsis. Developmental Cell 30: 437-448.
Hou X, Zhou J, Liu C, Liu L, Shen L, Yu H (2014) Nuclear Factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis. Nature Communications 5: 4601 doi: 10.1038/ncomms5601.
Teo ZWN, Song S, Wang Y-Q, Liu J, Yu H (2014) New insights into the regulation of inflorescence architecture. Trends in Plant Science 19: 158-165.
Shen L, Thong Z, Gong X, Shen Q, Gan Y, Yu H (2014) The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING GENES in Arabidopsis. Development 141: 1303-1312.
Liu L, Zhu Y, Shen L, Yu H (2013) Emerging insights into florigen transport. Current Opinion in Plant Biology 16: 607-613
Liu C, Teo ZWN, Bi Y, Song S, Xi W, Yang X, Yin Z, Yu H (2013) A conserved genetic pathway determines inflorescence architecture in Arabidopsis and rice. Developmental Cell 24: 612-622.
Ding L, Wang Y, Yu H (2013) Overexpression of DOSOC1, an ortholog of Arabidopsis SOC1, promotes flowering in the orchid Dendrobium Chao Parya Smile. Plant & Cell Physiology 54: 595-608. (Issue Highlight)
Liu L, Liu C, Hou X, Xi W, Shen L, Tao Z, Wang Y, Yu H (2012) FTIP1 is an essential regulator required for florigen transport. PLoS Biology 10: e1001313. (Issue Highlight)
An L, Zhou Z, Sun L, Yan A, Xi W, Yu N, Cai W, Chen X, Yu H, Schiefelbein J, Gan Y (2012) A zinc finger protein gene ZFP5 integrates phytohormone signaling to control root hair development in Arabidopsis. Plant Journal 72: 474-490.
Lee LYC, Hou X, Fang L, Fan S, Kumar PP, Yu H (2012) STUNTED mediates the control of cell proliferation by GA in Arabidopsis. Development 139: 1568-1576.
Tao Z, Shen L, Liu C, Liu Lu, Yan Y, Yu H (2012) Genome-wide identification of SOC1 and SVP targets during the floral transition in Arabidopsis. Plant Journal 70: 549-561. (Cover Article)
Shen L, Kang YGG, Liu L, Yu H (2011) The J-domain protein J3 mediates the integration of flowering signals in Arabidopsis. Plant Cell 23: 499-514.
Hou X, Lee LYC, Xia K, Yan Y, Yu H (2010) DELLAs Modulate Jasmonate Signaling via Competitive Binding to JAZs. Developmental Cell 19: 884-894.
Xi W, Liu C, Hou X, Yu H (2010) MOTHER OF FT AND TFL1 regulates seed germination through a negative feedback loop modulating ABA signaling in Arabidopsis. Plant Cell, 22: 1733-1748.
Wang Y, Liu C, Yang D, Yu H* and Liou YC* (2010) Pin1At encoding a peptidyl-prolyl cis/trans isomerase regulates flowering time in Arabidopsis. Molecular Cell 37: 112-122 (*Co-corresponding author).
Ng KH, Yu H, Toshiro I (2009) AGAMOUS controls GIANT KILLER, a multifunctional chromatin modifier in reproductive organ patterning and differentiation. PLoS Biology 7: e1000251.
Liu C, Thong Z, Yu H (2009) Coming into bloom: the specification of floral meristems. Development 136: 3379-3391.
Liu C, Xi W, Shen L, Tan C, Yu H (2009) Regulation of floral patterning by flowering time genes. Developmental Cell 16: 711-722. (Issue Highlight)
Hou X, Hu W-W, Shen L, Lee LYC, Tao Z, Han J-H, Yu H (2008) Global identification of DELLA target genes during Arabidopsis flower development. Plant Physiology 147: 1126-1142
Li D, Liu C, Shen L, Wu Y, Chen H, Robertson M, Helliwell CA, Ito T, Meyerowitz EM, Yu H (2008) A repressor complex governs the integration of flowering signals in Arabidopsis. Developmental Cell 15: 110-120.
Han P, García-Ponce B, Fonseca-Salazar G, Alvarez-Buylla ER, Yu H (2008) AGAMOUS-LIKE 17, a novel flowering promoter, acts in a FT-independent photoperiod pathway. Plant Journal 55: 253-265
Liu C, Chen H, Er HL, Soo HM, Kumar P, Han J-H, Liou YC, Yu H (2008) Direct interaction of AGL24 and SOC1 integrates flowering signals in Arabidopsis. Development 135: 1481-1491.
Ito T, Ng KH, Lim TS, Yu H, Meyerowitz EM (2007) The Homeotic Protein AGAMOUS Controls Late Stamen Development by Regulating a Jasmonate Biosynthetic Gene in Arabidopsis. Plant Cell 19: 3516-3529.
Gan Y, Yu H, Peng J, Broun P (2007) Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis thaliana. Plant Physiology 145: 1031-1042.
Chai D, Lee SM, Ng JH, Yu H (2007) L-methionine sulfoximine as a novel selection agent for genetic transformation of orchids. Journal of Biotechnology 131: 466–472.
Gan Y, Liu C, Yu H, Broun P (2007) Integration of cytokinin and gibberellin signalling by Arabidopsis transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate. Development 134: 2073-2081.
Liu C, Zhou J, Bracha-Drori K, Yalovsky S, Ito T, Yu H (2007) Specification of Arabidopsis floral meristem identity by repressing flowering time genes. Development 134: 1901-1910.
Gan Y, Kuminoto R, Liu C, Ratcliffe O, Yu H, Broun P (2006) GLABROUS INFLORESCENCE STEMS modulates gibberellin signaling in the regulation of epidermal differentiation and shoot maturation in Arabidospsis. Plant Cell 18: 1383-1395.
Xu Y, Teo LL, Zhou J, Kumar P*, Yu H* (2006) Floral organ identity genes in the Dendrobium orchids. Plant Journal 46: 54-68. (*Co-corresponding author)
Zhao Y, Medrano L, Ohashi K, Fletcher JC, Yu H, Sakai H, Meyerowitz EM (2004) HANABA TARANU is a GATA transcription factor that regulates shoot apical meristem and flower development in Arabidopsis. Plant Cell 16: 2586-2600.
Yu H, Ito T, Zhao Y, Peng J, Kumar P, Meyerowitz EM (2004) Floral homeotic genes are targets of gibberellin signaling in flower development. Proc. Natl. Acad. Sci. USA 101: 7827-7832.
Ito T, Wellmer F, Yu H, Das P, Ito N, Alves-Ferreira M, Riechmann JL, Meyerowitz EM (2004) The Arabidopsis organ identity protein AGAMOUS controls microsporogenesis through regulation of SPOROCYTELESS/NOZZLE. Nature 430: 356-360.
Yu H, Ito T, Wellmer F, Meyerowitz EM (2004) Repression of AGAMOUS-LIKE 24 is a crucial step in promoting flower development. Nature Genetics 36: 157-161.
Yang SH, Yu H, Xu Y, Goh CJ (2003) Investigation of cytokinin-deficient phenotypes in Arabidopsis by ectopic expression of orchid DSCKX1. FEBS Letters 555: 291-296.
Yu H, Xu Y, Tan EL, Kumar P (2002) AGAMOUS-LIKE 24, a dosage-dependent mediator of the flowering signals. Proc. Natl. Acad. Sci. USA 99: 16336-16341.
Yu H, Yang SH, Goh CJ (2002) Spatial and temporal expression of the orchid floral homeotic gene DOMADS1 is mediated by its upstream regulatory elements. Plant Mol. Biol. 49: 225-237.
Yu H, Goh CJ (2001) Molecular genetics of reproductive biology in orchids. Plant Physiol. 127: 1390-1393.
Yu H, Yang SH, Goh CJ (2000) DOH1, a class 1 knox gene, is required for maintenance of the basic plant architecture and floral transition in orchid. Plant Cell 12: 2143-2159
Yu H, Goh CJ (2000) Identification and characterization of three orchid MADS-box genes of the AP1/AGL9 subfamily during floral transition. Plant Physiol. 123: 1325-1336.
Shen L, Yu H (2011) Function of MADS-box proteins in the integration of flowering signals in Arabidopsis. In: Yaish M (ed.) The flowering process and its control in plants: gene expression and hormone interaction. Research Signpost, Kerala, India, pp 31-49.
Yu H, Xu Y (2007) Orchids. In: Pua EC and Davey MR (eds.) Biotechnology in Agriculture and Forestry, Vol 61. Springer-Verlag, Berlin Heidelberg, Germany, pp 273-288.
Yu H, Dhavale T, Yang S (2006) Molecular mechanisms of hormone functions in flowering. In: Teixeira da Silva JA. (ed.) Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues, Ed 1 Vol 1. Global Science Books, London, UK, pp 25-32.