Research @ CBIS

The NUS Centre for Bioimaging Sciences

The Art and Science of Biomolecular Imaging

CBIS is a multi-disciplinary research group bringing together people from Physics, Chemistry, Biology, Engineering and Computer Science. Our aim is to develop fluorescence, single molecule sensitive imaging and spectroscopy techniques and make them accessible to a wide range of users. Our research is centred on the investigation of biomolecular actions and functions under physiological relevant conditions to gain insights into important biological questions.

Founded in 2008, and opened in its current premises in 2010, CBIS was created as an interdisciplinary research centre combining existing groups in light, electron, and scanning probe microscopy into a centre to study the basic structure and dynamics of cellular systems over wide temporal and spatial ranges. CBIS acts especially in areas that offer collaboration with large-scale research programs such as Cancer RCE, SBIC, SMART Infectious Disease IRG, and mechanobiology.

Current Grants (2020)

Lead-PI Title Grant Type Grant Duration
Thorsten Wohland Investigation of molecular dynamics of ageing in cells and tissues MOE AcRF Tier 1 2019 to 2022
Thorsten Wohland The influence of EGFR-lipid interactions on signalling and trafficking MOE AcRF Tier 2 2017 to 2020
Thorsten Wohland Solving the conundrum of morphogen dynamics during tissue patterning MOE AcRF Tier 3 2017 to 2022
Thorsten Wohland SingaScope – a Singapore-wide microscopy infrastructure network NRF SIS 2019 to 2024
Paul Matsudaira Industry collaboration with Chugai for EM-related research CRA 2019 to 2022
Utkur Mirsaidov Image-enabled development for 3D microelectronics nanofabrication NRF CRP 2016 to 2021
Utkur Mirsaidov Study of the Mechanisms Governing the Synthesis of Nanoscale Materials MOE AcRF Tier 2 2019 to 2022
Utkur Mirsaidov Disruptive Fabrication Processes for Scalable Interconnects NRF CRP Just awarded (4 years)
Utkur Mirsaidov Study of the Mechanisms Governing the Nucleation and Growth of Metal-Organic Frameworks MOE AcRF Tier 2 Just awarded (3 years)
Lu Gan Electron cryotomography of condensed chromosomes in fission yeast YIA 2012 to 2017
Lu Gan Molecular organization of the kinetochore-microtubule interface in yeasts MOE AcRF Tier 2 2014 to 2017
Lu Gan Structural cell biology consequences of histone acetylation MOE AcRF Tier 1 2017 to 2019
Lu Gan Extreme nuclear remodeling in cellular quiescence MOE AcRF Tier 1 2019 to 2020
Winston Zhao Dissecting the spatio-temporal dynamics of chromatin remodeling in single human cells in health and cancer NMRC OF-YIRG 2019 to 2022
Christoph Winkler Healthy brain ageing – Analyzing mRNA editing and Fez1 function in the zebrafish nervous system MOE AcRF Tier 1 2019 to 2021
Christoph Winkler Control of osteoblast plasticity in a medaka osteoporosis model MOE AcRF Tier 2 2017 to 2020
Christoph Winkler A functional genomics approach to teleost musculoskeletal homeostasis NRF 2018 to 2021
Christoph Winkler Chemokine control of bone health NUS/BER 2019 to 2021
Lok Sheemei Understanding the possible structural variations of dengue virus particles and their implications in the design of effective vaccine and therapeutic agents NRFI 2016 to 2021
Lok Sheemei Studying Zika virus pathogenesis and the development of therapeutics, in vitro cell culture model and mouse model that display various diseases phenotypes NRF CRP 2017 to 2022
Yan Jie Single-molecule studies of micromechanics of DNA, protein, and their interactions MBI Seed 2019 to 2021
Yan Jie Mechanobiological applications of chemically induced dimerization (CID) MOE AcRF Tier 2 2020 to 2023
Yan Jie Understanding and Altering Mechanosening of Cells NRF 2016 to 2021
Yan Jie Single-molecule investigation of the mechanisms of R-loop formation and regulation FRC Tier 1 2018 to 2021
Duane Loh The search for spatio-temporal epidemiological motifs NUS Data Science Institute Grant 2017 to 2020
Duane Loh Experimental noise-robust phase retrieval for electron microscopy NUS Early Career Research Award 2018 to 2021
Duane Loh Data reduction for high throughput imaging of dose-sensitive materials MOE AcRF Tier 1 2020 to 2023