Senior Research Fellow

Contact Information:

Department of Biological Sciences
National University of Singapore
14 Science Drive 4
Singapore 117543

6516 7769
6779 2486

Academic Qualifications

2002 Ph. D. University of Toronto, Canada (major in Clinical Biochemistry)
1994 M. Sc. Xiamen University, China (major in Enzymology)
1991 B. SC. Xiamen University, China (major in Biochemistry)

Research Interests

  • Proteomics and mass spectrometry
  • Cancer biomarker discovery and cancer biology
  • Chemical proteomics and drug target identification
  • Mechanisms of water desalination in mangrove plants and euryhaline fish
  • Aquaporin biomimetic membrane for water desalination and reuse

Selected Publications

(from over 80 peer-reviewed papers)

  1. Wang J, Zhang J, Lee YM, Ng S, Shi Y, Hua ZC, Lin Q*, Shen HM. (2017) Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat Protoc. 12(2):279-288. (*Co-corresponding author)

  2. Zhang CJ, Wang JG, Zhang JB, Lee YM, Feng GX, Lim TK, Shen H-M, Lin Q*, Liu B. (2016) Mechanism-Guided Design and Synthesis of Mitochondria-targeting Artemisinin Analog with Enhanced Anticancer Activity. Angew. Chem. Int. Ed., DOI: 10.1002/anie.201607303. (*Co-corresponding author)

  3. Wang J, Zhang J, Lee YM, Koh PL, Ng S, Bao F, Lin Q* & Shen HM. Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy.  Autophagy. Published online: 27 Jul 2016. (*Co-corresponding author)

  4. Wang J, Gao L, Lee YM, Kalesh KA, Ong YS, Lim J, Jee JE, Sun H, Lee SS, Hua ZC, Lin Q*. Target identification of natural and traditional medicines with quantitative chemical proteomics approaches. Pharmacol Ther. 2016 Jun; 162:10-22.  (*Corresponding author)

  5. Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q*. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22; 6:10111. (*Corresponding author)

  6. Wang J, Zhang CJ, Zhang J, He Y, Lee YM, Chen S, Lim TK, Ng S, Shen HM, Lin Q* (2015) Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP). Sci Rep. 2015 Jan 20; 5:7896. (*Corresponding author)

  7. Wang J, Tan XF, Nguyen VS, Yang P, Zhou J, Gao M, Li Z, Lim TK, He Y, Ong CS, Lay Y, Zhang J, Zhu G, Lai SL, Ghosh D, Mok YK, Shen HM, Lin Q*. (2014) A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis. Mol. Cell. Proteomics.  13(3):876-86.  (*Corresponding author)

  8. Ghosh D, Li Z, Tan XF, Lim TK, Mao Y, Lin Q*. (2013) iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis. Mol. Cell. Proteomics. 12(7):1865-80.  (*Corresponding author)
    Ghosh D, Yu H, Tan XF, Lim TK, Zubaidah RM, Tan HT, Chung MC, Lin Q*. (2011) Identification of key players for colorectal cancer metastasis by iTRAQ™ quantitative proteomics profiling of isogenic SW480 and SW620 cell lines. Journal of Proteome Research, 10, 4373-4387. (*Corresponding author)

  9. Tan H. T., Lim T. K., Chung M. C., Lin Q*. (2011) iTRAQ™ Labeling Coupled with LC-MALDI Mass Spectrometry for Monitoring Temporal Response of Colorectal Cancer Cells to Butyrate Treatment. Methods in Molecular Biology, 716:207-24. (*Corresponding author)