Adjunct Assistant Professor

Contact Information:

Junior Principal Investigator (GIS)

Link to GIS webpage


Research Areas

Regulation and function of RNA modifications and epitranscriptomic factors in human diseases

Epitranscriptomics is an ever-expanding research on how RNA modifications regulate almost all aspects of RNA metabolism. While more than 170 RNA epigenetic modifications are known to exist, few have been extensively characterized. This offers an enormous untapped potential for discovering novel RNA modification defects that can contribute to disease progression. Our lab focuses on characterizing these RNA modifications by developing novel high-throughput sequencing techniques to map out epitranscriptomes at single-base resolutions. Our overall goal is to elucidate how these RNA modifications regulate cellular functions and in turn, contribute to human diseases.

Selected Publication

  1. Goh YT, Koh CWQ, Sim DY, Roca X*, Goh WSS*. METTL4 catalyzes N6-methylation of adenosines in U2 snRNA to regulate pre-mRNA splicing (2020) Biorxiv.

  2. Koh CWQ, Goh YT, Goh WSS*. Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes (2019) Nature Communications.

  3. Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS*. Single-Nucleotide-Resolution Sequencing of Human N6-Methyldeoxyadenosine Reveals Strand-Asymmetric Clusters Associated with SSBP1 on the Mitochondrial Genome (2018) Nucleic Acids Research (Highlighted in NAR Breakthrough Article).

  4. Goh WSS, Falciatori I, Tam OH, Burgess R, Meikar O, Kotaja N, Hammell M, Hannon GJ. piRNA-Directed Cleavage of Meiotic Transcripts Regulates Spermatogenesis (2015) Genes & Development.

  5. Rechavi O, Houri-Ze’evi L, Anava S, Goh WSS, Kerk SY, Hannon GJ, Hobert O. Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans (2014) Cell.

  6. Goh WSS, Seah JWE, Harrison EJ, Chen C, Hammell CM, Hannon GJ. A Genome-Wide RNAi Screen Identifies Factors Required for Distinct Stages of C. elegans piRNA Biogenesis (2014) Genes & Development.

  7. Aow JS, Xue X, Run JQ, Lim GF, Goh WS, Clarke ND. Differential Binding of the Related Transcription Factors Pho4 and Cbf1 can Tune the Sensitivity of Promoters to Different Levels of an Induction Signal (2013) Nucleic Acids Research.

  8. Goh WS, Orlov Y, Li J, Clarke ND. Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local (2010) PLoS Computational Biology