CHEMICAL BIOLOGY AND DRUG DISCOVERY LAB
Protein dynamics is central to biological function. Our group’s research interests are in probing protein dynamics in cell signalling with a focus on allostery, conformational dynamics of intrinsically disordered signalling enzymes, transmembrane receptor signalling and targeted drug discovery.
Signalling pathways of interest include cAMP signalling, two-component signalling (histidine-aspartate phosphorelays) in bacteria and lower eukaryotes, transmembrane signalling, osmosensing and viral maturation.
Protein dynamics is probed by multiple biophysical tools including amide hydrogen/deuterium (H/D) exchange mass spectrometry (HDXMS) and ion mobility mass spectrometry (IM-MS). Our goal is to integrate protein dynamics with structural tools for describing biological function.
OUR RESEARCH IN PICTURES
Phosphodiesterase-protein kinase A (PDE-PKA) interactions
Histidine flexibility in osmosensing
Amide hydrogen/deuterium exchange in proteins
In vivo interaction of phosphodiesterase with protein kinase A
Local flexibility around ligand-binding site
Conformational stabilisation in viral maturation
Dynamics govern selectivity in protein-DNA interactions
Osmosensing via helix-coil transitions in EnvZ
Different exchange kinetics in HDXMS
OmpF pore dynamics in membrane signaling
HDXMS identification of binding and allosteric sites
HDMXS probes dynamic profiles of proteins
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