GANESH ANAND LAB

CHEMICAL BIOLOGY AND DRUG DISCOVERY LAB

Protein dynamics is central to biological function. Our group’s research interests are in probing protein dynamics in cell signalling with a focus on allostery, conformational dynamics of intrinsically disordered signalling enzymes, transmembrane receptor signalling and targeted drug discovery.

 

Signalling pathways of interest include cAMP signalling, two-component signalling (histidine-aspartate phosphorelays) in bacteria and lower eukaryotes, transmembrane signalling, osmosensing and viral maturation.

 

Protein dynamics is probed by multiple biophysical tools including amide hydrogen/deuterium (H/D) exchange mass spectrometry (HDXMS) and ion mobility mass spectrometry (IM-MS). Our goal is to integrate protein dynamics with structural tools for describing biological function.

 

OUR RESEARCH IN PICTURES

For Prospective Students

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