LIM TIT MENG

LIM TIT MENG

Associate Professor

Contact Information:

Department of Biological Sciences
National University of Singapore
14 Science Drive 4
Singapore 117543

Curriculum Vitae

dbsltm@nus.edu.sg


Academic Qualification:

BSc (Direct Honours, 1 st Class) NUS, 1984
PhD University of Cambridge, UK, 1987

Executive Programmes Attended:

Senior Management Programme: Leadership and Governance, LKY School of Public Policy, NUS, July 2006
Senior Management Programmes, School of Business in NUS, February to April 2007

Career History

Lecturer, Department of Zoology, NUS (1987-1991)
Senior Lecturer, Department of Zoology, NUS (1992-1998)
Associate Professor, Department of Biological Sciences, NUS (1998-Present)
Assistant Chief Executive, Science Centre Singapore (Aug 2007 – Jul 2009)

Leadership Held:

  • Founder member of the Institute of Molecular Agrobiology (1994-1996)
  • Sub-Dean, Faculty of Science, NUS (1996-1998)
  • Director, Bioscience Centre, NUS (1998-2000)
  • Deputy Head, Department of Biological Sciences, NUS (1998-2003)
  • Core Curriculum, University Scholar Programme, Area Coordinator (1999-2000)
  • Programme Director, JTC in-house training course ‘Introduction to Life Sciences’ and DSO in-house training course ‘Crash Course in Life Sciences’ (2000-2001)
  • Biosensor Focus Interest Group Founding member and leader (1999-2005)
  • Vice Dean, Faculty of Science, NUS (June 2003 – Feb 2008 )
  • Vice President, Singapore Institute of Biology (2001-2005)
  • President, Singapore Institute of Biology (2006 – 2009)
  • Scientific Programme Chair for the joint KI-NUS Life Science Symposium 2002
  • Co-chair for the Singapore Institute of Biology 30th Anniversary International Conference on Biology in Asia, 2004
  • Chairman, Department Strategic Planning Retreat, (1999-2003)
  • Chairman, Faculty Strategic Planning Retreat, 2004
  • Chairman, Non-academics Faculty Review Committee (2003-2007)
  • Chairman, Faculty Safety and Health Management Committee (2003-2007)
  • Faculty Incident Commander in crisis management (2004-2007)
  • Chairman, School Outreach Task Force (2003-2007)
  • Chairman, Faculty Alumni Relation Task Force (2003-2007)
  • Chairman, Science Research Programme (2003-2007)
  • Chairman, Science Mentorship programme (2003-2007)
  • Chairman, Scientific Review Committee for Singapore Science and Engineering Fair (From 2007)
  • Chairman, Faculty Task Force for ‘Dinosaurs: A T. rex named Sue and friends’ exhibition at the Singapore Science Centre (2006)
  • Co-chairman, University Task Force for ‘Cultures of Creativity: Nobel Museum Centennial Exhibition’ at NUS (2006/7)
  • Chairman, Singapore Biology Olympiad (2001-2005)
  • Founder and Director, BioNano International Singapore Pte Ltd (since 2003)
  • Founder of a private Kids Club (since 1996)

 

Advisory Board Member:

  • SingaporeScience Centre (2007)
  • PSB Academy Board (2007-2008)
  • Meridian Junior College Advisory Board (2006 to present)
  • SEAMEO BIOTROP Governing Board Member of Singapore (‘98-01)
  • Science Centre Singapore Redevelopment Project EXCO member(from 2009)

 

Other Honours and Awards

  • NUS Undergrad Scholarships 1982, 1983
  • Cambridge Churchill College Overseas Scholarship 1984-87
  • UK Overseas Research Scholarship 1984-87
  • Japan-Singapore Promotion for Science Fellowship 1991
  • Commonwealth Fellowship 1995-96
  • Faculty of Science Teaching Excellence Awards 1993, 1994, 1998, 1999, 2000, 2001, 2002
  • NUS Top 100 Excellent Teachers, 2002
  • Outstanding Contributor Award in Science Mentorship Programme 2004; 2006; 2009
  • Outstanding Mentorship Award in Science Mentorship Programme 2006
  • Outstanding Contributor Award in Science Research Programme for service rendered spanning 1988 to 2007
  • National University of Singapore Quality Service Award 2007
  • Ministry of Education Service to Education Award 2009

 

External Examiner:

  • Singapore Polytechnic Biotechnology Programme (2007 to 2011)
  • Ngee Ann Polytechnic Chemical and Life Sciences Programme (2007 to 2009)

 

Consultancy:

  • Consultant to AsknLearn Pte Ltd and developed e-modules for school teachers on ‘Introduction to Life Sciences’ and ‘Introduction to Nanotechnology’
  • Consultant to Zenitant Pte Ltd on ‘Learning through Life Science Trails’ and related teachers workshops
  • Helped MOE in developing two Life Sciences Guide Books and one Lab Safety Guidebook for school use
  • Life Science consultant to Hwa Chong Institute, River Valley High School, ACS (I), Victoria Junior College
  • Consultant to Skill Development Centre as a biology content expert for the development of an e-learning package for biology 2001-2003
  • Advisor to the Jurong Bird Park on bird molecular sexing matters 2001-2003
  • International Biology Olympiad Jury member (2003, 2005)

 

Review Committees:

  • A*STAR BMRC Grant Local Review Penal (2001-2003)
  • NUS University Grant Review Committee (2003-2006)
  • MOE ‘A’ Level Biology Curriculum Review Committee (2000/01) (2009/10)
  • MOE Life Science Curriculum Review Working Committee member, 2000
  • MOE Life Science Guide Books for Teachers, Co-Chair of Working Committee, September 2000- February 2001
  • NUS High School for Science and Maths Curriculum Planning Committee (2002/03)
  • Faculty Outstanding Researcher Award Selection Panel (2003-2006)
  • MOE Co-ordinating Committee on the Revised Gifted Education Framework (2006)
  • MOE Resource Panel for the Review of School Lab Safety Regulations (2006)

 

Journal Reviewer:

  • BIOTROPICA (regional journal) Histology and Histopathology (International journal)
  • Brain Research (International journal)
  • International Journal of Nanoscience (International journal)
  • Materials Chemistry and Physics (MCP) (International journal)
  • Nucleic Acid Research (International journal)
  • Journal of Electroanalytical Chemistry (International journal)
  • Advanced Structure Materials (International journal)
  • Analytical Chemistry (International journal)
  • Journal of Zhejiang University – Science B (international journal)

 

Selected recent publications related to cell biology:

  1. Jacqueline LY Chee, XL Guan, JY Lee, B Dong, SM Leong, EH Ong, AKF Liou and TM Lim (2005) Compensatory Caspase Activation in MPP+-induced Cell Death in Dopaminergic Neurons. Cellular and Molecular Life Sciences. 62: 227-238.

  2. Chou AM, Sae- Lim V, Hutmacher DW and Lim TM (2006) Tissue Engineering of a Periodontal Ligament-Alveolar Bone Graft Construct. Int J Oral & Maxillofacial Implants . 21(4), 526-36.

  3. Zhou YF, Sae-Lim V, Chou AM, Hutmacher DW and Lim TM (2006) Does seeding density affect in vitro mineral nodules formation in novel composite scaffolds? J Biomed Mater Res A, 78(1), 183-193.

  4. Zhou ZD, Yap BP, Gung A, Leong SM, ST Ang and Lim TM (2006) Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type and mutant i±-synuclein. Experimental Cell Research. 312: 156-170.

  5. Teh CH, Lam KK, Loh CC, Loo JM, Yan T, Lim TM (2006) Neuronal PAS Domain Protein 1 Is a Transcriptional Repressor and Requires Arylhydrocarbon Nuclear Translocator for Its Nuclear Localization. J Biol Chem 281(45):34617-34629

  6. Teh CH, Loh CC, Lam KK, Loo JM, Yan T, Lim TM (2007) Neuronal PAS Domain Protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. J Neurosci Res 85: 1762-1773.

  7. Zhou, Z, S Y Kerk and T M Lim (2008) “Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteosome inhibitor MG132”. REE RADICAL RESEARCH, 42, no. 5: 456-466.

  8. Zhou, Z, S Y Kerk, G XIONG and T M Lim (2009) “Dopamine auto-oxidation aggravates non-apoptotic cell death induced by overexpression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells’. Journal of Neurochemistry, 108, no. 3: 601-610.

  9. Zhou, Z and T M Lim (2009), “Dopamine (DA) induced irreversible proteasome inhibition via DA -derived quinones’. FREE RADICAL RESEARCH, 43, no. 4: 417-430.

  10. Zhou, Z and T M Lim (2009), “Roles of Glutathione (GSH) in Dopamine (DA) Oxidation Studied by Improved Tandem HPLC Plus ESI-MS.”. NEUROCHEMICAL RESEARCH, 34, no. 2: 316-326.

Selected Recent Publications Related to BioMEMS and Nanotechnology:

  1. Qasem Ramadan, Victor Samper, Daniel Poenar, Zhu Liang Chen Yu and Lim Tit Meng (2005) Simultaneous cell lysis and bead trapping in a continuous flow microfluidic device. Sensor Actuat B-Chem, 113, 944-955.

  2. Hui Chen, Chew Kiat Heng, Poenar Daniel Puiu, Xiao Dong Zhou, Ai Cheng Lee, Tit Meng Lim and Swee Ngin Tan (2005) Detection of Saccharomyces cerevisiae immobilized on self-assembled monolayer (SAM) of alkanethiolate using electrochemical impedance spectroscopy . Analytica Chimica Acta Volume 554, Issues 1-2, 4: 52-59.

  3. Ye, J -S, H -F Cui, X Liu, T M Lim, W -D Zhang and F S Sheu (2005), ‘Preparation and characterization of well-aligned carbon nanotubesruthenium oxide nanocomposites for supercapacitors’. Small, 1: 560-565.

  4. Ye, J -S, X Liu, H -F Cui, W -D Zhang, F S Sheu and T M Lim (2005) ‘Electrochemical oxidation of multi-walled carbon nanotubes and its application to electrochemical double layer capacitors’. Electrochemistry Communications, 7: 249-255.

  5. A.C. Lee, J.S. Ye, S.N. Tan, D. Poenar, F.S. Sheu, C.K. Heng and T.M. Lim (2006) Carbon Nanotube-based Labels for Sensitive Nucleic Acids Detection. Nanotech. Vol. 2, p. 232- 235.

  6. Hui, WC, L Yobas, V Samper, C K Heng, S Liw, H Ji, Y Chen, L Cong, J Li and T M Lim (2007) ‘Microfluidic systems for extracting nucleic acids for DNA and RNA analysis’. SENSORS AND ACTUATORS A-PHYSICAL, 133: 335-339

  7. LEE, A C, JS Ye, SN Tan, DP Poenar, F S Sheu, C K Heng and T M Lim (2007), ‘Carbon nanotube based labels for highly sensitive colorimetric and aggregation based visual detection of nucleic acids’. NANOTECHNOLOGY, 18, no. 45.

  8. Yobas, L, H Ji, WC Hui, Y Chen, T M Lim, C K Heng and DL Kwong, Nucleic Acid Extraction, Amplification, and Detection on Si-Based Microfluidic Platforms’. IEEE JOURNAL OF SOLID STATE CIRCUITS, 42, no. 8 (2007): 1803-1813.

  9. LEE, A C, G Liu, C K Heng, SN Tan, T M Lim and Y Lin (2008), ‘Sensitive electrochemical detection of horseradish peroxidase at disposable screen printed carbon electrode.’  ELECTROANALYSIS, 20, no. 18: 2040-2046.

  10. LEE, A C, Z Dai, B Chen, H Wu, J Wang, A Zhang, L Zhang, T M Lim and Y Lin (2008), ‘Electrochemical Branched DNA Assay for Polymerase Chain Reaction Free Detection and Quantification of Oncogenes in Messenger RNA’. ANALYTICAL CHEMISTRY, 80, no. 24: 9402-9410.

 

Patents

  1. JI, H., YOBAS, L., CHEN, Y., HUI, W. C., HENG, C. K., & LIM, T. M. (2007). IMMOBILIZATION UNIT AND DEVICE FOR ISOLATION OF NUCLEIC ACID MOLECULES

  2. Miao, Y., Chen, Y., Lim, T. M., & Heng, C. K. (2009). Shallow multi-well plastic chip for thermal multiplexing

  3. SAMPER, V., HONGMIAO, J., YU, C., KIAT, H., Chew, & LIM, T., Meng. (2005). NUCLEIC ACID PURIFICATION CHIP

  4. Miao, Y., Chen, Y., Lim, T. M., & Heng, C. K. (2008). Shallow multi-well plastic chip for thermal multiplexing

  5. MIAO, Y., CHEN, Y., LIM, T., Meng, & HENG, C., Kiat. (2004). SHALLOW MULTI-WELL PLASTIC CHIP FOR THERMAL MULTIPLEXING

  6. ZOU, Q., CHEN, Y., SINGH, J., LIM, T., Meng, YAN, T., & HENG, C., Kiat. (2003). SINGLE WAFER FABRICATION OF INTEGRATED MICRO-FLUIDIC SYSTEM

  7. Miao, Y., Chen, Y., Lim, T. M., & Heng, C. K. (2004). Shallow multi-well plastic chip for thermal multiplexing

  8. Zou, Q., Chen, Y., Singh, J., Lim, T. M., Yan, T., & Heng, C. K. (2004). Process to fabricate an integrated micro-fluidic system on a single wafer

  9. Zou, Q., Chen, Y., Singh, J., Lim, T. M., Yan, T., & Heng, C. K. (2003). Single wafer fabrication of integrated micro-fluidic system

  10. Zou, Q., Sridhar, U., Chen, Y., Lim, T. M., Zachariah, E. S., & Yan, T. (2003). Miniaturized thermal cycler

  11. Zou, Q., Sridhar, U., Chen, Y., Lim, T. M., Zachariah, E. S., & Yan, T. (2003). Miniaturized thermal cycler

  12. Zou, Q., Sridhar, U., Chen, Y., Lim, T. M., Zachariah, E. S., & Yan, T. (2002). Miniaturized thermal cycler

  13. Zou, Q., Sridhar, U., Chen, Y., Lim, T. M., Zachariah, E. S., & Yan, T. (2002). MINIATURIZED THERMAL CYCLER

  14. Zou, Q., Sridhar, U., Chen, Y., Lim, T. M., Zachariah, E. S., & Yan, T. (2002). Miniaturized thermal cycler

  15. Samper, V., Hongmiao, J., Yu, C., Kiat, H. C., & Lim, T.M. (2005). Nucleic acid purification chip