The NUS Centre for Bioimaging Sciences

Cryoelectron Microscope facility

The CBIS Cryoelectron Microscope Facility is a prominent member of a select group of state-of-the-art, high-end cryoelectron microscopy facilities in the world. By minimizing EMI, reducing relative humidity to 30%, and together with the exceptionally quiet acoustic and low mechanical vibration levels, all microscopes in the facility are able to easily reach designed performance specifications. From this perspective both FEI and JEOL have informed us that the Centre is among their best TEM installations world-wide.

In addition to the four TEMs, the 30% RH rooms also contain instruments for cryofreezing of samples and cryosectioning. A separate room in S1A houses a high-pressure freezing instrument for ultra-fast freezing of thick samples.

The instruments are supported and maintained by excellent technical staff trained in biological sample preparation and imaging. The CBIS Cryoelectron Microscopy Facility is the most advanced TEM facility in Singapore and offers use of its equipment and resources at competitive rates.